The use and interpretation of statistical models for risk of diseases with several, or many, etiological risk factors have been widely discussed. David Clayton revisits and illustrates these debates using results from an analysis of the genetics of type 1 diabetes.
The association between undermethylation and chromosomal rearrangement in gibbons suggests a correlation between epigenetic state and structural genome variation in evolution. Judith Brown and Rachel O'Neill offer an accompanying Perspective.
The authors identify the cells and the receptor molecule responsible for the uptake and degradation of the Necrotic serpin in Drosophila melanogaster. The scavenging of serpin/proteinase complexes may be a critical step in the regulation of proteolytic cascades.
This study demonstrates how the power of mouse knockout data can be systematically exploited to gain a better understanding of genetically heterogeneous neurological disorders.
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology. View a list of Google Scholar citations and read about our current impact factor of 8.9.
E-mail Alerts
RSS (What is RSS?)
Join PLoSRead the PLoS Blog 
and contribute your views on scientific research and open-access publishing.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.
