Bruce A. Hamilton and Benjamin D. Yu argue that modifier genes derived from natural variation may provide a bias for nodes in genetic networks that have greater intrinsic plasticity and whose therapeutic manipulation may therefore be more resilient to side effects than conventional targets.
This study identifies the novel LINT complex as an important repressor of germline-specific genes that are derepressed in malignant brain tumours in Drosophila.
The authors used whole-genome data on small insertions and deletions within transposable elements from chicken and zebra finch to demonstrate clear links between recombination rate and a number of attributes of reduced DNA content.
This study reports genomic prediction for starvation stress resistance and startle response in Drosophila melanogaster using ~2.5 million single-nucleotide polymorphisms determined by sequencing the Drosophila Genetic Reference Panel population of inbred lines.
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Genetics; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Genetics; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology.
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