In the latest in a collection of interviews, Jane Gitschier talks to Radoje Drmanac whose scientific career has been driven by his ambition to sequence human genomic DNA using oligonucleotides, and whose company now specializes in full human genome sequencing.
This study shows that DNA replication timing can serve as the basis for the inheritance of functional centromeres at specific chromosomal sites, representing a novel mechanism of epigenetic inheritance.
By comparing the repertoires of chemosensory Ionotropic Receptors among both closely- and distantly-related species, the authors observe dynamic patterns of expansion and divergence of these receptor families in organisms occupying very different ecological niches.
The authors find that transcripts regulated by Wor1 have many unusual properties, several of which are also observed for transcripts regulated during the development of mammalian embryonic stem cells, suggesting that they may be general hallmarks of cell differentiation.
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Genetics; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Genetics; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
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