Carola Vinuesa and Thomas Preiss write a Perspective on an article from Johanna Schott and colleagues, who show that in the early stages of macrophage activation, translational derepression is a major mechanism that induces feedback inhibitors to dampen inflammation.
Image credit: Wikimedia Commons public domain
Several laboratory rodent models exist for human absence seizures, including one caused by mutation of a gene called Gria4. While studying Gria4, Wayne N. Frankel and colleagues noticed that a mouse strain called C3H can suppress or enhance the frequency and severity of Gria4-associated spike-wave discharges in a perplexing manner.
Genes involved in defense against pathogens are among the most variable in plants. A drawback of this extreme variation is that at times the plant mistakes itself for an enemy. Marco Todesco and colleagues show that this hybrid necrosis can be triggered by interactions between variants of a single gene.
Primordial germ cells are highly sensitive to genetic perturbations affecting DNA repair. Yunhai Luo and colleagues show that primordial germ cells lacking the Fancm gene respond by slowing cell division. They identify the genetic pathway responsible for this protective response.
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