Search
Advanced Search
Publish with PLoS We want to publish your work
 

Review

Modifier Genes and the Plasticity of Genetic Networks in Mice

article image

Bruce A. Hamilton and Benjamin D. Yu argue that modifier genes derived from natural variation may provide a bias for nodes in genetic networks that have greater intrinsic plasticity and whose therapeutic manipulation may therefore be more resilient to side effects than conventional targets.

 

Featured Research

LINT, a Novel dL(3)mbt-Containing Complex, Represses Malignant Brain Tumour Signature Genes

article image

This study identifies the novel LINT complex as an important repressor of germline-specific genes that are derepressed in malignant brain tumours in Drosophila.

 

Recombination Drives Vertebrate Genome Contraction

article image

The authors used whole-genome data on small insertions and deletions within transposable elements from chicken and zebra finch to demonstrate clear links between recombination rate and a number of attributes of reduced DNA content.

 

Using Whole-Genome Sequence Data to Predict Quantitative Trait Phenotypes in Drosophila melanogaster

article image

This study reports genomic prediction for starvation stress resistance and startle response in Drosophila melanogaster using ~2.5 million single-nucleotide polymorphisms determined by sequencing the Drosophila Genetic Reference Panel population of inbred lines.

 

PLoS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology.

 

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.