A multi-journal collection of Essays, Perspectives, and Reviews, produced with support from Google.org and accompanied by an audio interview discussion, describes how genomics can revolutionize our understanding of emerging infectious disease. PLoS Genetics contributes two Reviews: one by Kate Seib, Gordon Dougan, and Rino Rappuoli; the other by Daniel Falush.
These observations raise the possibility that the involvement of meiotic HORMA-domain proteins in the regulation of homologue interactions is conserved in mammals.
The authors propose a model in which HTZ-1, directly or indirectly, serves to restrict the dosage compensation complex to the X chromosome by acting as or regulating the activity of an autosomal repellant.
These results highlight an important biochemical characteristic of fusion genes in that they can serve as biological shortcuts, allowing a single fusion of two enzymes to functionally replace three independent enzymes.
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS ONE; PLoS Neglected Tropical Diseases
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