In this Review, Kacy L. Gordon and Ilya Ruvinsky synthesize the results of 230 experiments performed on insects and nematodes in which regulatory DNA from one species was used to drive gene expression in another species.
The authors focus on how the promoter regions of genes affect noise and ask whether levels of promoter-mediated noise are correlated with genes’ functional attributes, using data for over 60% of all promoters in Escherichia coli.
This study highlights the importance of Themis as a new target gene that could participate in the pathogenesis of immune diseases characterized by chronic inflammation resulting from a defect in the regulatory T cell compartment.
The authors describe mechanisms employed by the bacterium Salmonella enterica to survive bile: adaptation, mutation, and non-mutational preadaptation.
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Genetics; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Genetics; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology.
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