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PLoS Collection on the Genomics of Emerging Infectious Disease

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A multi-journal collection of Essays, Perspectives, and Reviews, produced with support from Google.org and accompanied by an audio interview discussion, describes how genomics can revolutionize our understanding of emerging infectious disease. PLoS Genetics contributes two Reviews: one by Kate Seib, Gordon Dougan, and Rino Rappuoli; the other by Daniel Falush.

 

Featured Research

Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase

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These observations raise the possibility that the involvement of meiotic HORMA-domain proteins in the regulation of homologue interactions is conserved in mammals.

 

Restricting Dosage Compensation Complex Binding to the X Chromosomes by H2A.Z/HTZ-1

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The authors propose a model in which HTZ-1, directly or indirectly, serves to restrict the dosage compensation complex to the X chromosome by acting as or regulating the activity of an autosomal repellant.

 

1 + 1 = 3: A Fusion of 2 Enzymes in the Methionine Salvage Pathway of Tetrahymena thermophila Creates a Trifunctional Enzyme That Catalyzes 3 Steps in the Pathway

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These results highlight an important biochemical characteristic of fusion genes in that they can serve as biological shortcuts, allowing a single fusion of two enzymes to functionally replace three independent enzymes.

 

PLoS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology.

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