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Perspective

The Williams-Beuren Syndrome—A Window into Genetic Variants Leading to the Development of Cardiovascular Disease

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Gregory N. Adams and Alvin H. Schmaier provide a Perspective on the work of Victoria Campuzano and colleagues, which used a mouse model of elastin deficiency to better define the contribution of NOX–mediated oxidative stress to the cardiovascular phenotype of Williams-Beuren syndrome.

 

Featured Research

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

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These results suggest that pharmacological down-regulation of one or more sphingolipids may provide a means to reduce age-related diseases and increase lifespan in eukaryotes.

 

Inter-Homolog Crossing-Over and Synapsis in Arabidopsis Meiosis Are Dependent on the Chromosome Axis Protein AtASY3

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This study identifies AtASY3, a component of the proteinaceous axes that organize the chromosomes during meiosis in Arabidopsis.

 

Loss of Function of the Cik1/Kar3 Motor Complex Results in Chromosomes with Syntelic Attachment That Are Sensed by the Tension Checkpoint

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The authors show that syntelic attachments can be induced in budding yeast by inactivating the Cik1/Kar3 motor complex.

 

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PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Genetics; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases

PLoS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology.

 

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