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Research Article

A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target

  • Taixiang Saur,

    Affiliations: Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America, Mailman Research Center, McLean Hospital, Belmont, Massachusetts, United States of America

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  • Sarah E. DeMarco,

    Affiliation: Mailman Research Center, McLean Hospital, Belmont, Massachusetts, United States of America

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  • Angelica Ortiz,

    Affiliation: Department of Molecular Pathology, University of Texas–MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Gregory R. Sliwoski,

    Affiliation: Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Limin Hao,

    Affiliations: Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America, Mailman Research Center, McLean Hospital, Belmont, Massachusetts, United States of America

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  • Xin Wang,

    Affiliations: Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America, Mailman Research Center, McLean Hospital, Belmont, Massachusetts, United States of America

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  • Bruce M. Cohen,

    Affiliations: Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America, Mailman Research Center, McLean Hospital, Belmont, Massachusetts, United States of America

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  • Edgar A. Buttner mail

    ebuttner@partners.org

    Affiliations: Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America, Mailman Research Center, McLean Hospital, Belmont, Massachusetts, United States of America, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: February 28, 2013
  • DOI: 10.1371/journal.pgen.1003313

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