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Research Article

An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila

  • Colin D. Meiklejohn,

    Affiliation: Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America

    Current address: Department of Biology, Indiana University, Bloomington, Indiana, United States of America

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  • Marissa A. Holmbeck,

    Affiliation: Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, United States of America

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  • Mohammad A. Siddiq,

    Affiliation: Department of Biology, Indiana University, Bloomington, Indiana, United States of America

    Current address: Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

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  • Dawn N. Abt,

    Affiliation: Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America

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  • David M. Rand,

    Affiliation: Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America

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  • Kristi L. Montooth

    Affiliation: Department of Biology, Indiana University, Bloomington, Indiana, United States of America

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  • Published: January 31, 2013
  • DOI: 10.1371/journal.pgen.1003238

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