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Research Article

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

  • Elisabeth M. Lodder equal contributor,

    equal contributor Contributed equally to this work with: Elisabeth M. Lodder, Brendon P. Scicluna

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Brendon P. Scicluna equal contributor,

    equal contributor Contributed equally to this work with: Elisabeth M. Lodder, Brendon P. Scicluna

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Annalisa Milano,

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Albert Y. Sun,

    Affiliation: The Ion Channel Research Unit, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Hao Tang,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Carol Ann Remme,

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Perry D. Moerland,

    Affiliation: Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Michael W. T. Tanck,

    Affiliation: Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Geoffrey S. Pitt,

    Affiliation: The Ion Channel Research Unit, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Douglas A. Marchuk,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Connie R. Bezzina mail

    C.R.Bezzina@amc.uva.nl

    Affiliation: Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Published: December 06, 2012
  • DOI: 10.1371/journal.pgen.1003113

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Linked Articles

Defining the Pathways Underlying the Prolonged PR Interval in Atrioventricular Conduction Disease

Jerry Curran, Peter J. Mohler
Perspective | published 6 Dec 2012 | PLOS Genetics
doi:10.1371/journal.pgen.1003154