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Research Article

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

  • John P. Miller,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Bridget E. Yates,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Ismael Al-Ramahi,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Ari E. Berman,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Mario Sanhueza,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Eugene Kim,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Maria de Haro,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Francesco DeGiacomo,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Cameron Torcassi,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Jennifer Holcomb,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Juliette Gafni,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Sean D. Mooney,

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Juan Botas,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Lisa M. Ellerby mail,

    lellerby@buckinstitute.org (LME); rhughes@buckinstitute.org (REH)

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Robert E. Hughes mail

    lellerby@buckinstitute.org (LME); rhughes@buckinstitute.org (REH)

    Affiliation: The Buck Institute for Research on Aging, Novato, California, United States of America

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.pgen.1003042

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