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Heterozygous Mutations in DNA Repair Genes and Hereditary Breast Cancer: A Question of Power

  • Nathan A. Ellis mail,

    naellis@uic.edu (NE); offitk@mskcc.org (KO)

    Affiliation: Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Kenneth Offit mail

    naellis@uic.edu (NE); offitk@mskcc.org (KO)

    Affiliation: Department of Medicine, Memorial Sloan-Kettering Cancer Center, Program in Cancer Biology and Genetics, Sloan-Kettering Institute, New York, New York, United States of America

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  • Published: September 27, 2012
  • DOI: 10.1371/journal.pgen.1003008

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Exome Sequencing Identifies Rare Deleterious Mutations in DNA Repair Genes FANCC and BLM as Potential Breast Cancer Susceptibility Alleles

Ella R. Thompson, Maria A. Doyle, Georgina L. Ryland, Simone M. Rowley, David Y. H. Choong, Richard W. Tothill, Heather Thorne, Daniel R. Barnes, Jason Li, Jason Ellul, Gayle K. Philip, ...
Research Article | published 27 Sep 2012 | PLOS Genetics
doi:10.1371/journal.pgen.1002894