Advertisement
Research Article

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

  • Courtney A. Lovejoy,

    Affiliation: Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

    X
  • Wendi Li,

    Affiliation: Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

    X
  • Steven Reisenweber,

    Affiliation: Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

    X
  • Supawat Thongthip,

    Affiliation: Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

    X
  • Joanne Bruno,

    Affiliation: Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

    X
  • Titia de Lange mail,

    delange@mail.rockefeller.edu

    Affiliation: Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York, United States of America

    X
  • Saurav De,

    Affiliation: Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    X
  • John H. J. Petrini,

    Affiliation: Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    X
  • Patricia A. Sung,

    Affiliation: Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    X
  • Maria Jasin,

    Affiliation: Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    X
  • Joseph Rosenbluh,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Yaara Zwang,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Barbara A. Weir,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Charlie Hatton,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Elena Ivanova,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Laura Macconaill,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Megan Hanna,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • William C. Hahn,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Neal F. Lue,

    Affiliation: Department of Microbiology and Immunology, W. R. Hearst Microbiology Research Center, Weill Medical College, Cornell University, New York, New York, United States of America

    X
  • Roger R. Reddel,

    Affiliations: Children's Medical Research Institute, Westmead, New South Wales, Australia, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia

    X
  • Yuchen Jiao,

    Affiliation: Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America

    X
  • Kenneth Kinzler,

    Affiliation: Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America

    X
  • Bert Vogelstein,

    Affiliations: Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America, Howard Hughes Medical Institutions, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America

    X
  • Nickolas Papadopoulos,

    Affiliation: Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, United States of America

    X
  • Alan K. Meeker,

    Affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • for the ALT Starr Cancer Consortium
  • Published: July 19, 2012
  • DOI: 10.1371/journal.pgen.1002772

Media Coverage of this Article

Found additional news media or blog coverage for the article? Please let us know.