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Research Article

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

  • Jian Li,

    Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America

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  • R. Alan Harris,

    Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Sau Wai Cheung,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Cristian Coarfa,

    Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Mira Jeong,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Margaret A. Goodell,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Lisa D. White,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Ankita Patel,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Sung-Hae Kang,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Chad Shaw,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • A. Craig Chinault,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Tomasz Gambin,

    Affiliation: Institute of Computer Science, Warsaw University of Technology, Warsaw, Poland

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  • Anna Gambin,

    Affiliation: Institute of Informatics, Warsaw University, Warsaw, Poland

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  • James R. Lupski,

    Affiliations: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America, Texas Children's Hospital, Houston, Texas, United States of America

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  • Aleksandar Milosavljevic mail

    amilosav@bcm.edu

    Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Published: May 17, 2012
  • DOI: 10.1371/journal.pgen.1002692

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Linked Articles

Comment on “Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome”

Corey T. Watson, Paras Garg, Andrew J. Sharp
Viewpoints | published 28 Feb 2013 | PLOS Genetics
doi:10.1371/journal.pgen.1003332

Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association between Hypomethylation and Genomic Instability

R. Alan Harris, Chad Shaw, Jian Li, Sau Wai Cheung, Cristian Coarfa, Mira Jeong, Margaret A. Goodell, Lisa D. White, Ankita Patel, Sung-Hae Kang, A. Craig Chinault, ...
Viewpoints | published 28 Feb 2013 | PLOS Genetics
doi:10.1371/journal.pgen.1003333