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Research Article

Evidence for Positive Selection on a Number of MicroRNA Regulatory Interactions during Recent Human Evolution

  • Jingjing Li equal contributor,

    equal contributor Contributed equally to this work with: Jingjing Li, Yu Liu

    Affiliations: Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

    Current address: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

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  • Yu Liu equal contributor,

    equal contributor Contributed equally to this work with: Jingjing Li, Yu Liu

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Canada, The Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

    X
  • Xiaofeng Xin,

    Affiliations: Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

    Current address: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Taehyung Simon Kim,

    Affiliation: Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada

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  • Eduardo Aguiar Cabeza,

    Affiliation: The Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

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  • Jie Ren,

    Affiliation: Department of Physics and Centre for Computational Science and Engineering, National University of Singapore, Singapore, Singapore

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  • Rasmus Nielsen,

    Affiliation: Departments of Integrative Biology and Statistics, University of California Berkeley, Berkeley, California, United States of America

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  • Jeffrey L. Wrana mail,

    wrana@lunenfeld.ca (JLW); Zhaolei.Zhang@utoronto.ca (ZZ)

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Canada, The Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

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  • Zhaolei Zhang mail

    wrana@lunenfeld.ca (JLW); Zhaolei.Zhang@utoronto.ca (ZZ)

    Affiliations: Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

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  • Published: March 22, 2012
  • DOI: 10.1371/journal.pgen.1002578

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