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Research Article

Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

  • Maureen J. Koslowski,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Zora Teltschik,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Julia Beisner,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Elke Schaeffeler,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Guoxing Wang,

    Affiliation: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany

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  • Irmgard Kübler,

    Affiliation: Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany

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  • Michael Gersemann,

    Affiliations: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany, Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany

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  • Rachel Cooney,

    Affiliation: Medical Science Division, John Radcliffe Hospital, Oxford, United Kingdom

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  • Derek Jewell,

    Affiliation: Medical Science Division, John Radcliffe Hospital, Oxford, United Kingdom

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  • Walter Reinisch,

    Affiliation: Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria

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  • Séverine Vermeire,

    Affiliation: Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium

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  • Paul Rutgeerts,

    Affiliation: Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium

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  • Matthias Schwab,

    Affiliations: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany, Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital, Tübingen, Germany

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  • Eduard F. Stange,

    Affiliation: Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany

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  • Jan Wehkamp mail

    jan.wehkamp@ikp-stuttgart.de

    Affiliations: Dr. Margarete-Fischer-Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany, Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany

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  • Published: February 23, 2012
  • DOI: 10.1371/journal.pgen.1002523

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