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Research Article

Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis

  • Jahan-Yar Parsa,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Shaliny Ramachandran,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Ahmad Zaheen,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Rajeev M. Nepal,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Anat Kapelnikov,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Antoaneta Belcheva,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Maribel Berru,

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Diana Ronai,

    Affiliation: Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

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  • Alberto Martin mail

    alberto.martin@utoronto.ca

    Affiliation: Department of Immunology, University of Toronto, Toronto, Canada

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  • Published: February 09, 2012
  • DOI: 10.1371/journal.pgen.1002518

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