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Research Article

A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

  • Marianne Chabod,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Christophe Pedros,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Lucille Lamouroux,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Céline Colacios,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Isabelle Bernard,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Dominique Lagrange,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Daniela Balz-Hara,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Jean-Francois Mosnier,

    Affiliation: Université de Nantes, Faculté de Médecine, EA Biométadys, Nantes, France

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  • Christian Laboisse,

    Affiliation: Université de Nantes, Faculté de Médecine, EA Biométadys, Nantes, France

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  • Nathalie Vergnolle,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Olivier Andreoletti,

    Affiliation: UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France

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  • Marie-Paule Roth,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Roland Liblau,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Gilbert J. Fournié,

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Abdelhadi Saoudi mail,

    abdelhadi.saoudi@inserm.fr

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Anne S. Dejean

    Affiliations: UMR Inserm, U1043, Toulouse, France, UMR CNRS, U5282, Toulouse, France, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France

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  • Published: January 19, 2012
  • DOI: 10.1371/journal.pgen.1002461

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