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Research Article

Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals

  • Yingleong Chan equal contributor,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Oddgeir L. Holmen equal contributor,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    Affiliations: HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway, St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway

    X
  • Andrew Dauber equal contributor,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    Affiliations: Broad Institute, Cambridge, Massachusetts, United States of America, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Lars Vatten,

    Affiliation: Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway

    X
  • Aki S. Havulinna,

    Affiliation: National Institute for Health and Welfare, Helsinki, Finland

    X
  • Frank Skorpen,

    Affiliation: Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway

    X
  • Kirsti Kvaløy,

    Affiliation: HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway

    X
  • Kaisa Silander,

    Affiliations: National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

    X
  • Thutrang T. Nguyen,

    Affiliation: Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Cristen Willer,

    Affiliation: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Michael Boehnke,

    Affiliation: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Markus Perola,

    Affiliations: National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Estonian Genome Project, University of Tartu, Tartu, Estonia

    X
  • Aarno Palotie,

    Affiliations: Broad Institute, Cambridge, Massachusetts, United States of America, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

    X
  • Veikko Salomaa,

    Affiliation: National Institute for Health and Welfare, Helsinki, Finland

    X
  • Kristian Hveem,

    Affiliation: HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway

    X
  • Timothy M. Frayling equal contributor,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    Affiliation: Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

    X
  • Joel N. Hirschhorn equal contributor mail,

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    joelh@broadinstitute.org(JNH); michael.weedon@pms.ac.uk (MNW)

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Michael N. Weedon equal contributor mail

    equal contributor Contributed equally to this work with: Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

    joelh@broadinstitute.org(JNH); michael.weedon@pms.ac.uk (MNW)

    Affiliation: Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

    X
  • Published: December 29, 2011
  • DOI: 10.1371/journal.pgen.1002439

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