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Research Article

A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis

  • Elena Lissina,

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada

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  • Brian Young,

    Affiliation: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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  • Malene L. Urbanus,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

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  • Xue Li Guan,

    Affiliations: Department of Biological Sciences, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Department of Biochemistry, University of Geneva, Geneva, Switzerland

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  • Jonathan Lowenson,

    Affiliation: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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  • Shawn Hoon,

    Affiliation: Molecular Engineering Lab, Agency for Science, Technology, and Research, Singapore, Singapore

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  • Anastasia Baryshnikova,

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada

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  • Isabelle Riezman,

    Affiliation: Department of Biochemistry, University of Geneva, Geneva, Switzerland

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  • Magali Michaut,

    Affiliation: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada

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  • Howard Riezman,

    Affiliation: Department of Biochemistry, University of Geneva, Geneva, Switzerland

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  • Leah E. Cowen,

    Affiliation: Department of Molecular Genetics, University of Toronto, Toronto, Canada

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  • Markus R. Wenk,

    Affiliation: Department of Biological Sciences, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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  • Steven G. Clarke,

    Affiliation: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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  • Guri Giaever,

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Department of Pharmacy and Pharmaceutical Sciences, University of Toronto, Toronto, Canada

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  • Corey Nislow mail

    corey.nislow@utoronto.ca

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

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  • Published: October 20, 2011
  • DOI: 10.1371/journal.pgen.1002332

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