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Research Article

Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

  • Olga Gorlova equal contributor mail,

    equal contributor Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

    oygorlov@mdanderson.org (O Gorlova); martin@ipb.csic.es (J Martin)

    Affiliation: Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Jose-Ezequiel Martin equal contributor,

    equal contributor Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

    Affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

    X
  • Blanca Rueda equal contributor,

    equal contributor Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

    Affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

    X
  • Bobby P. C. Koeleman equal contributor,

    equal contributor Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

    Affiliation: Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Jun Ying,

    Affiliation: Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Maria Teruel,

    Affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

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  • Lina-Marcela Diaz-Gallo,

    Affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

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  • Jasper C. Broen,

    Affiliation: Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

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  • Madelon C. Vonk,

    Affiliation: Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

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  • Carmen P. Simeon,

    Affiliation: Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain

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  • Behrooz Z. Alizadeh,

    Affiliation: University Medical Centre Groningen, Department of Epidemiology, Groningen, The Netherlands

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  • Marieke J. H. Coenen,

    Affiliation: Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

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  • Alexandre E. Voskuyl,

    Affiliation: VU University Medical Center, Amsterdam, The Netherlands

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  • Annemie J. Schuerwegh,

    Affiliation: Department of Rheumatology, University of Leiden, Leiden, The Netherlands

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  • Piet L. C. M. van Riel,

    Affiliation: Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

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  • Marie Vanthuyne,

    Affiliation: Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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  • Ruben van 't Slot,

    Affiliation: Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Annet Italiaander,

    Affiliation: Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Roel A. Ophoff,

    Affiliation: Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Nicolas Hunzelmann,

    Affiliation: Department of Dermatology, University of Cologne, Cologne, Germany

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  • Vicente Fonollosa,

    Affiliation: Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain

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  • Norberto Ortego-Centeno,

    Affiliation: Servicio de Medicina Interna, Hospital Clínico Universitario, Granada, Spain

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  • Miguel A. González-Gay,

    Affiliation: Servicio de Reumatología, Hospital Marqués de Valdecilla, Santander, Spain

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  • Francisco J. García-Hernández,

    Affiliation: Servicio de Medicina Interna, Hospital Virgen del Rocio, Sevilla, Spain

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  • María F. González-Escribano,

    Affiliation: Servicio de Inmunología, Hospital Virgen del Rocío, Sevilla, Spain

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  • Paolo Airo,

    Affiliation: Rheumatology Unit and Chair, Spedali Civili, Università degli Studi, Brescia, Italy

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  • Jacob van Laar,

    Affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom

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  • Jane Worthington,

    Affiliation: Department of Rheumatology and Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

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  • Roger Hesselstrand,

    Affiliation: Department of Clinical Sciences, Division of Rheumatology, Lund University, Lund, Sweden

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  • Vanessa Smith,

    Affiliation: Ghent University, Ghent, Belgium

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  • Filip de Keyser,

    Affiliation: Ghent University, Ghent, Belgium

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  • Fredric Houssiau,

    Affiliation: Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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  • Meng May Chee,

    Affiliation: Centre for Rheumatic Diseases, Glasgow Royal Infirmary Glasgow, United Kingdom

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  • Rajan Madhok,

    Affiliation: Centre for Rheumatic Diseases, Glasgow Royal Infirmary Glasgow, United Kingdom

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  • Paul G. Shiels,

    Affiliation: Department of Surgery, Western Infirmary Glasgow, University of Glasgow, Glasgow, United Kingdom

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  • Rene Westhovens,

    Affiliation: Katholieke Universiteit Leuven, Leuven, Belgium

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  • Alexander Kreuter,

    Affiliation: Department of Dermatology, Josefs-Hospital, Ruhr University Bochum, Germany

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  • Elfride de Baere,

    Affiliation: Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium

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  • Torsten Witte,

    Affiliation: Hannover Medical School, Hannover, Germany

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  • Leonid Padyukov,

    Affiliation: Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Annika Nordin,

    Affiliation: Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Raffaella Scorza,

    Affiliation: Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy

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  • Claudio Lunardi,

    Affiliation: Department of Medicine, Policlinico GB Rossi, University of Verona, Italy

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  • Benedicte A. Lie,

    Affiliation: Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway

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  • Anna-Maria Hoffmann-Vold,

    Affiliation: Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway

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  • Øyvind Palm,

    Affiliation: Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway

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  • Paloma García de la Peña,

    Affiliation: Servicio de Reumatología, Hospital Ramón y Cajal, Madrid, Spain

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  • Patricia Carreira,

    Affiliation: Hospital 12 de Octubre, Madrid, Spain

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  • Spanish Scleroderma Group equal contributor,

    equal contributor Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group

    Affiliation: For membership of the Spanish Scleroderma Group, please see Text S1.

    X
  • John Varga,

    Affiliation: Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • Monique Hinchcliff,

    Affiliation: Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

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  • Annette T. Lee,

    Affiliation: Feinstein Institute of Medical Research, Manhasset, New York, United States of America

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  • Pravitt Gourh,

    Affiliation: The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

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  • Christopher I. Amos,

    Affiliation: Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Frederick M. Wigley,

    Affiliation: The Johns Hopkins University Medical Center, Baltimore, Maryland, United States of America

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  • Laura K. Hummers,

    Affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • J. Hummers,

    Affiliation: The Johns Hopkins University Medical Center, Baltimore, Maryland, United States of America

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  • J. Lee Nelson,

    Affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Gabriella Riemekasten,

    Affiliation: Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany

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  • Ariane Herrick,

    Affiliation: Department of Rheumatology and Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom

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  • Lorenzo Beretta,

    Affiliation: Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy

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  • Carmen Fonseca,

    Affiliation: Centre for Rheumatology, Royal Free and University College School, London, United Kingdom

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  • Christopher P. Denton,

    Affiliation: Centre for Rheumatology, Royal Free and University College School, London, United Kingdom

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  • Peter K. Gregersen,

    Affiliation: Feinstein Institute of Medical Research, Manhasset, New York, United States of America

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  • Sandeep Agarwal,

    Affiliation: The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

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  • Shervin Assassi,

    Affiliation: The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

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  • Filemon K. Tan,

    Affiliation: The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

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  • Frank C. Arnett ,

    Affiliation: The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

    These authors also contributed equally to this work.

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  • Timothy R. D. J. Radstake ,

    Affiliation: Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    These authors also contributed equally to this work.

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  • Maureen D. Mayes ,

    Affiliation: The University of Texas Health Science Center–Houston, Houston, Texas, United States of America

    These authors also contributed equally to this work.

    X
  • Javier Martin mail

    oygorlov@mdanderson.org (O Gorlova); martin@ipb.csic.es (J Martin)

    Affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain

    These authors also contributed equally to this work.

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  • Published: July 14, 2011
  • DOI: 10.1371/journal.pgen.1002178

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Linked Articles

Correction: Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Jun Ying, Maria Teruel, Lina-Marcela Diaz-Gallo, Jasper C. Broen, Madelon C. Vonk, Carmen P. Simeon, Behrooz Z. Alizadeh, ...
Correction | published 25 Aug 2011 | PLOS Genetics
doi:10.1371/annotation/3aeebb2e-64e5-4548-8d65-1f2d5dfeb073

Correction: Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Jun Ying, Maria Teruel, Lina-Marcela Diaz-Gallo, Jasper C. Broen, Madelon C. Vonk, Carmen P. Simeon, Behrooz Z. Alizadeh, ...
Correction | published 25 Aug 2011 | PLOS Genetics
doi:10.1371/annotation/7a52649c-0942-4bd8-a5d3-3cdacca03cd8