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Research Article

The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study

  • Alexandra C. Nica,

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

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  • Leopold Parts,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Daniel Glass,

    Affiliation: Department of Twin Research, King's College London, London, United Kingdom

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  • James Nisbet,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Amy Barrett,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Magdalena Sekowska,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Mary Travers,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Simon Potter,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Elin Grundberg,

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Twin Research, King's College London, London, United Kingdom

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  • Kerrin Small,

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Twin Research, King's College London, London, United Kingdom

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  • Åsa K. Hedman,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Veronique Bataille,

    Affiliation: Department of Twin Research, King's College London, London, United Kingdom

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  • Jordana Tzenova Bell,

    Affiliations: Department of Twin Research, King's College London, London, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Gabriela Surdulescu,

    Affiliation: Department of Twin Research, King's College London, London, United Kingdom

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  • Antigone S. Dimas,

    Affiliations: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Catherine Ingle,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Frank O. Nestle,

    Affiliation: St. John's Institute of Dermatology, King's College London, London, United Kingdom

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  • Paola di Meglio,

    Affiliation: St. John's Institute of Dermatology, King's College London, London, United Kingdom

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  • Josine L. Min,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Alicja Wilk,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Christopher J. Hammond,

    Affiliation: Department of Twin Research, King's College London, London, United Kingdom

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  • Neelam Hassanali,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Tsun-Po Yang,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Stephen B. Montgomery,

    Affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

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  • Steve O'Rahilly,

    Affiliation: University of Cambridge Metabolic Research Labs, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Cecilia M. Lindgren,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Krina T. Zondervan,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Nicole Soranzo,

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Twin Research, King's College London, London, United Kingdom

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  • Inês Barroso,

    Affiliations: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, University of Cambridge Metabolic Research Labs, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Richard Durbin,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Kourosh Ahmadi,

    Affiliation: Department of Twin Research, King's College London, London, United Kingdom

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  • Panos Deloukas mail,

    emmanouil.dermitzakis@unige.ch (ETD); tim.spector@kcl.ac.uk (TDS); mark.mccarthy@drl.ox.ac.uk (MIM); panos@sanger.ac.uk (PD)

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Mark I. McCarthy mail,

    emmanouil.dermitzakis@unige.ch (ETD); tim.spector@kcl.ac.uk (TDS); mark.mccarthy@drl.ox.ac.uk (MIM); panos@sanger.ac.uk (PD)

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

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  • Emmanouil T. Dermitzakis mail,

    emmanouil.dermitzakis@unige.ch (ETD); tim.spector@kcl.ac.uk (TDS); mark.mccarthy@drl.ox.ac.uk (MIM); panos@sanger.ac.uk (PD)

    Affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

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  • Timothy D. Spector mail,

    emmanouil.dermitzakis@unige.ch (ETD); tim.spector@kcl.ac.uk (TDS); mark.mccarthy@drl.ox.ac.uk (MIM); panos@sanger.ac.uk (PD)

    Affiliation: Department of Twin Research, King's College London, London, United Kingdom

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  • The MuTHER Consortium
  • Published: February 03, 2011
  • DOI: 10.1371/journal.pgen.1002003

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