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Research Article

Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development

  • Ulla Sovio equal contributor,

    equal contributor Contributed equally to this work with: Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, Robert Lawrence

    Affiliations: Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom, The London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Dennis O. Mook-Kanamori equal contributor,

    equal contributor Contributed equally to this work with: Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, Robert Lawrence

    Affiliations: Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, The Generation R Study, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Nicole M. Warrington equal contributor,

    equal contributor Contributed equally to this work with: Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, Robert Lawrence

    Affiliation: School of Women's and Infants' Health, The University of Western Australia, Perth, Australia

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  • Robert Lawrence equal contributor,

    equal contributor Contributed equally to this work with: Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, Robert Lawrence

    Affiliation: Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Perth, Australia

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  • Laurent Briollais,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada

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  • Colin N. A. Palmer,

    Affiliation: Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom

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  • Joanne Cecil,

    Affiliation: Bute Medical School, University of St Andrews, St Andrews, United Kingdom

    Current address: School of Medicine, University of St. Andrews, St. Andrews, United Kingdom

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  • Johanna K. Sandling,

    Affiliation: Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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  • Ann-Christine Syvänen,

    Affiliation: Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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  • Marika Kaakinen,

    Affiliations: Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland

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  • Lawrie J. Beilin,

    Affiliation: School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia

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  • Iona Y. Millwood,

    Affiliations: Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom

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  • Amanda J. Bennett,

    Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom

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  • Jaana Laitinen,

    Affiliation: Finnish Institute of Occupational Health, Oulu, Finland

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  • Anneli Pouta,

    Affiliation: Department of Lifecourse and Services, National Institute of Health and Welfare, Oulu, Finland

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  • John Molitor,

    Affiliation: Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom

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  • George Davey Smith,

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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  • Yoav Ben-Shlomo,

    Affiliation: Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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  • Vincent W. V. Jaddoe,

    Affiliations: Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, The Generation R Study, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Lyle J. Palmer,

    Affiliation: Ontario Institute for Cancer Research and Samuel Lunenfeld Research Institute, Toronto, Canada

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  • Craig E. Pennell,

    Affiliation: School of Women's and Infants' Health, The University of Western Australia, Perth, Australia

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  • Tim J. Cole mail,

    tim.cole@ich.ucl.ac.uk (TJC); n.j.timpson@bristol.ac.uk (NJT)

    Affiliation: MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom

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  • Mark I. McCarthy,

    Affiliations: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

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  • Marjo-Riitta Järvelin,

    Affiliations: Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Lifecourse and Services, National Institute of Health and Welfare, Oulu, Finland

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  • Nicholas J. Timpson mail,

    tim.cole@ich.ucl.ac.uk (TJC); n.j.timpson@bristol.ac.uk (NJT)

    Affiliations: MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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  • Early Growth Genetics Consortium
  • Published: February 17, 2011
  • DOI: 10.1371/journal.pgen.1001307

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