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Research Article

Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells

  • Karsten Jürchott,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Ralf-Jürgen Kuban,

    Affiliation: Laboratory of Functional Genomics, Universitätsmedizin Berlin, Berlin, Germany

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  • Till Krech,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Nils Blüthgen,

    Affiliation: Institute for Theoretical Biology, Humboldt University, Berlin, Germany

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  • Ulrike Stein,

    Affiliation: Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Wolfgang Walther,

    Affiliation: Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Christian Friese,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Szymon M. Kiełbasa,

    Affiliations: Institute for Theoretical Biology, Humboldt University, Berlin, Germany, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Ute Ungethüm,

    Affiliation: Laboratory of Functional Genomics, Universitätsmedizin Berlin, Berlin, Germany

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  • Per Lund,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Thomas Knösel,

    Affiliation: Institute of Pathology, Friedrich-Schiller-University Jena, Jena, Germany

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  • Wolfgang Kemmner,

    Affiliations: Max Delbrück Center for Molecular Medicine, Berlin, Germany, Charité Comprehensive Cancer Center, Berlin, Germany

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  • Markus Morkel,

    Affiliations: Max Delbrück Center for Molecular Medicine, Berlin, Germany, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Johannes Fritzmann,

    Affiliation: Charité Comprehensive Cancer Center, Berlin, Germany

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  • Peter M. Schlag,

    Affiliation: Charité Comprehensive Cancer Center, Berlin, Germany

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  • Walter Birchmeier,

    Affiliation: Max Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Tammo Krueger,

    Affiliation: Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Silke Sperling,

    Affiliation: Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Christine Sers,

    Affiliation: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany

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  • Hans-Dieter Royer,

    Affiliations: Center of Advanced European Studies and Research, Bonn, Germany, Institute of Human Genetics and Anthropology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany

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  • Hanspeter Herzel,

    Affiliation: Institute for Theoretical Biology, Humboldt University, Berlin, Germany

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  • Reinhold Schäfer mail

    reinhold.schaefer@charite.de

    Affiliations: Laboratory of Molecular Tumor Pathology, Universitätsmedizin Berlin, Berlin, Germany, Laboratory of Functional Genomics, Universitätsmedizin Berlin, Berlin, Germany, Charité Comprehensive Cancer Center, Berlin, Germany

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  • Published: December 02, 2010
  • DOI: 10.1371/journal.pgen.1001231

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