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Research Article

Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways

  • Emily J. Capra equal contributor,

    equal contributor Contributed equally to this work with: Emily J. Capra, Barrett S. Perchuk

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Barrett S. Perchuk equal contributor,

    equal contributor Contributed equally to this work with: Emily J. Capra, Barrett S. Perchuk

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Emma A. Lubin,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Orr Ashenberg,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Jeffrey M. Skerker,

    Affiliations: Department of Bioengineering, University of California Berkeley, Berkeley, California, United States of America, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

    X
  • Michael T. Laub mail

    laub@mit.edu

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Published: November 24, 2010
  • DOI: 10.1371/journal.pgen.1001220

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