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Research Article

Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A

  • Carola Marzi equal contributor,

    equal contributor Contributed equally to this work with: Carola Marzi, Eva Albrecht

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Eva Albrecht equal contributor,

    equal contributor Contributed equally to this work with: Carola Marzi, Eva Albrecht

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Pirro G. Hysi,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Vasiliki Lagou,

    Affiliations: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Melanie Waldenberger,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Anke Tönjes,

    Affiliations: Department of Medicine, University of Leipzig, Leipzig, Germany, Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany

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  • Inga Prokopenko,

    Affiliations: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Katharina Heim,

    Affiliation: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Hannah Blackburn,

    Affiliation: Wellcome Trust Sanger Institute Genome Campus, Hinxton, United Kingdom

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  • Janina S. Ried,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Marcus E. Kleber,

    Affiliation: LURIC, Freiburg, Germany

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  • Massimo Mangino,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Barbara Thorand,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Annette Peters,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Christopher J. Hammond,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Harald Grallert,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Bernhard O. Boehm,

    Affiliation: Division of Endocrinology, Department of Medicine, University of Ulm, Ulm, Germany

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  • Peter Kovacs,

    Affiliation: Interdisciplinary Centre for Clinical Research, Department of Internal Medicine III, University of Leipzig, Leipzig, Germany

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  • Ludwig Geistlinger,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Holger Prokisch,

    Affiliations: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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  • Bernhard R. Winkelmann,

    Affiliation: Cardiology Group Sachsenhausen, Frankfurt, Germany

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  • Tim D. Spector,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • H.-Erich Wichmann,

    Affiliations: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, Klinikum Grosshadern, Munich, Germany

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  • Michael Stumvoll,

    Affiliation: Department of Medicine, University of Leipzig, Leipzig, Germany

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  • Nicole Soranzo,

    Affiliations: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute Genome Campus, Hinxton, United Kingdom

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  • Winfried März,

    Affiliations: SynLab Medizinisches Versorgungszentrum Heidelberg, Eppelheim, Germany, Institut für Public Health, Sozialmedizin und Epidemiologie, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria

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  • Wolfgang Koenig,

    Affiliation: Department of Internal Medicine II – Cardiology, University of Ulm Medical Center, Ulm, Germany

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  • Thomas Illig mail,

    illig@helmholtz-muenchen.de (TI); christian.gieger@helmholtz-muenchen.de (CG)

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    These authors also contributed equally to this work.

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  • Christian Gieger mail

    illig@helmholtz-muenchen.de (TI); christian.gieger@helmholtz-muenchen.de (CG)

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    These authors also contributed equally to this work.

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  • Published: November 18, 2010
  • DOI: 10.1371/journal.pgen.1001213

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