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Research Article

The Fitness Landscapes of cis-Acting Binding Sites in Different Promoter and Environmental Contexts

  • Ryan K. Shultzaberger,

    Affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Daniel S. Malashock,

    Affiliation: Graduate Group in Comparative Biochemistry, University of California Berkeley, Berkeley, California, United States of America

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  • Jack F. Kirsch,

    Affiliations: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Department of Chemistry, University of California Berkeley, Berkeley, California, United States of America

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  • Michael B. Eisen mail

    mbeisen@berkeley.edu

    Affiliations: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California, United States of America, California Institute of Quantitative Biosciences, University of California Berkeley, Berkeley, California, United States of America, Genomics Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Published: July 29, 2010
  • DOI: 10.1371/journal.pgen.1001042

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