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Research Article

Multi-Variant Pathway Association Analysis Reveals the Importance of Genetic Determinants of Estrogen Metabolism in Breast and Endometrial Cancer Susceptibility

  • Yen Ling Low equal contributor,

    equal contributor Contributed equally to this work with: Yen Ling Low, Yuqing Li, Keith Humphreys

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

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  • Yuqing Li equal contributor,

    equal contributor Contributed equally to this work with: Yen Ling Low, Yuqing Li, Keith Humphreys

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

    X
  • Keith Humphreys equal contributor,

    equal contributor Contributed equally to this work with: Yen Ling Low, Yuqing Li, Keith Humphreys

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Anbupalam Thalamuthu,

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

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  • Yi Li,

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

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  • Hatef Darabi,

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Sara Wedrén,

    Affiliation: Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Carine Bonnard,

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

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  • Kamila Czene,

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Mark M. Iles,

    Affiliation: Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom

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  • Tuomas Heikkinen,

    Affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

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  • Kristiina Aittomäki,

    Affiliation: Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland

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  • Carl Blomqvist,

    Affiliations: Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland, Department of Oncology, Radiology, and Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden

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  • Heli Nevanlinna,

    Affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

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  • Per Hall mail,

    liuj3@gis.a-star.edu.sg (JL); liue@gis.a-star.edu.sg (ETL); Per.Hall@ki.se (PH)

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Edison T. Liu mail,

    liuj3@gis.a-star.edu.sg (JL); liue@gis.a-star.edu.sg (ETL); Per.Hall@ki.se (PH)

    Affiliation: Cancer Biology, Genome Institute of Singapore, Singapore, Singapore

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  • Jianjun Liu mail

    liuj3@gis.a-star.edu.sg (JL); liue@gis.a-star.edu.sg (ETL); Per.Hall@ki.se (PH)

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

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  • Published: July 01, 2010
  • DOI: 10.1371/journal.pgen.1001012

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