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Research Article

Alternative Splicing Events Are a Late Feature of Pathology in a Mouse Model of Spinal Muscular Atrophy

  • Dirk Bäumer,

    Affiliation: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • Sheena Lee,

    Affiliation: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • George Nicholson,

    Affiliation: Department of Statistics, University of Oxford, Oxford, United Kingdom

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  • Joanna L. Davies,

    Affiliation: Department of Statistics, University of Oxford, Oxford, United Kingdom

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  • Nicholas J. Parkinson,

    Affiliation: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • Lyndsay M. Murray,

    Affiliation: Centre for Integrative Physiology and Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh Medical School, Edinburgh, United Kingdom

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  • Thomas H. Gillingwater,

    Affiliation: Centre for Integrative Physiology and Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh Medical School, Edinburgh, United Kingdom

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  • Olaf Ansorge,

    Affiliation: Department of Neuropathology, John Radcliffe Hospital, Oxford, United Kingdom

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  • Kay E. Davies,

    Affiliation: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • Kevin Talbot mail

    kevin.talbot@clneuro.ox.ac.uk

    Affiliations: MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Published: December 18, 2009
  • DOI: 10.1371/journal.pgen.1000773

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