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Research Article

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

  • Stephen N. Sansom,

    Affiliation: Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Dean S. Griffiths equal contributor,

    equal contributor Contributed equally to this work with: Dean S. Griffiths, Andrea Faedo

    Affiliation: Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

    Current address: Cambridge Institute for Medical Research, Cambridge, United Kingdom

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  • Andrea Faedo equal contributor,

    equal contributor Contributed equally to this work with: Dean S. Griffiths, Andrea Faedo

    Affiliation: Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, California, United States of America

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  • Dirk-Jan Kleinjan,

    Affiliation: Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

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  • Youlin Ruan,

    Affiliation: Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, California, United States of America

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  • James Smith,

    Affiliation: Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Veronica van Heyningen,

    Affiliation: Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

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  • John L. Rubenstein,

    Affiliation: Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, California, United States of America

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  • Frederick J. Livesey mail

    rick@gurdon.cam.ac.uk

    Affiliation: Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Published: June 12, 2009
  • DOI: 10.1371/journal.pgen.1000511

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