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Research Article

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

  • Melanie Kolz equal contributor,

    equal contributor Contributed equally to this work with: Melanie Kolz, Toby Johnson

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

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  • Toby Johnson equal contributor,

    equal contributor Contributed equally to this work with: Melanie Kolz, Toby Johnson

    Affiliations: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland

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  • Serena Sanna ,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Cagliari, Italy

    These authors also contributed equally to this work.

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  • Alexander Teumer ,

    Affiliation: Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

    These authors also contributed equally to this work.

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  • Veronique Vitart ,

    Affiliation: MRC Human Genetics Unit, IGMM, Western General Hospital, Crewe Road, Edinburgh, United Kingdom

    These authors also contributed equally to this work.

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  • Markus Perola ,

    Affiliations: Department of Chronic Disease Prevention, Institute of Health and Welfare, Helsinki, Finland, FIMM, Institute of Molecular Medicine, Helsinki, Finland

    These authors also contributed equally to this work.

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  • Massimo Mangino ,

    Affiliation: DTR Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

    These authors also contributed equally to this work.

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  • Eva Albrecht ,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

    These authors also contributed equally to this work.

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  • Chris Wallace ,

    Affiliation: The Diabetes Inflammation Laboratory, Cambridge Institute of Medical Research, Cambridge University, Cambridge, United Kingdom

    These authors also contributed equally to this work.

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  • Martin Farrall ,

    Affiliations: Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    These authors also contributed equally to this work.

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  • Åsa Johansson ,

    Affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    These authors also contributed equally to this work.

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  • Dale R. Nyholt ,

    Affiliation: Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia

    These authors also contributed equally to this work.

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  • Yurii Aulchenko,

    Affiliation: Department of Epidemiology, Erasmus MC Rotterdam, Rotterdam, The Netherlands

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  • Jacques S. Beckmann,

    Affiliations: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Sven Bergmann,

    Affiliations: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Murielle Bochud,

    Affiliation: University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland

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  • Morris Brown,

    Affiliation: Clinical Pharmacology Unit, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom

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  • Harry Campbell,

    Affiliation: Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom

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  • for the EUROSPAN Consortium,
  • John Connell,

    Affiliation: Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Anna Dominiczak,

    Affiliation: Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Georg Homuth,

    Affiliation: Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

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  • Claudia Lamina,

    Affiliations: Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany, Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria

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  • Mark I. McCarthy,

    Affiliations: The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, National Institute for Health Research, Oxford Biomedical Research Centre, University of Oxford, Headington, Oxford, United Kingdom

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  • for the ENGAGE Consortium,
  • Thomas Meitinger,

    Affiliation: Institute of Human Genetics, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

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  • Vincent Mooser,

    Affiliation: Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

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  • Patricia Munroe,

    Affiliation: The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, England

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  • Matthias Nauck,

    Affiliation: Institut für Klinische Chemie und Laboratoriumsmedizin, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

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  • John Peden,

    Affiliations: Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Holger Prokisch,

    Affiliation: Institute of Human Genetics, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

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  • Perttu Salo,

    Affiliations: Department of Chronic Disease Prevention, Institute of Health and Welfare, Helsinki, Finland, FIMM, Institute of Molecular Medicine, Helsinki, Finland

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  • Veikko Salomaa,

    Affiliation: Department of Chronic Disease Prevention, Institute of Health and Welfare, Helsinki, Finland

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  • Nilesh J. Samani,

    Affiliation: Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom

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  • David Schlessinger,

    Affiliation: Laboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Manuela Uda,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Cagliari, Italy

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  • Uwe Völker,

    Affiliation: Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

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  • Gérard Waeber,

    Affiliation: Department of Medicine and Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Dawn Waterworth,

    Affiliation: Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

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  • Rui Wang-Sattler,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

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  • Alan F. Wright,

    Affiliation: MRC Human Genetics Unit, IGMM, Western General Hospital, Crewe Road, Edinburgh, United Kingdom

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  • Jerzy Adamski,

    Affiliation: Genome Analysis Centre, Institute for Experimental Genetics, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

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  • John B. Whitfield,

    Affiliation: Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia

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  • Ulf Gyllensten,

    Affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

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  • James F. Wilson,

    Affiliation: Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom

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  • Igor Rudan,

    Affiliations: Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom, Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia, Gen-Info, Zagreb, Croatia

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  • Peter Pramstaller,

    Affiliations: Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University Lübeck, Department of Neurology, Central Hospital, Bolzano, Italy

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  • Hugh Watkins,

    Affiliations: Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • for the PROCARDIS Consortium,
  • Angela Doering,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

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  • H.-Erich Wichmann,

    Affiliations: Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany, IBE, Chair of Epidemiology, University of Munich, Germany

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  • for the KORA Study,
  • Tim D. Spector,

    Affiliation: DTR Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Leena Peltonen,

    Affiliations: FIMM, Institute of Molecular Medicine, Helsinki, Finland, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Henry Völzke,

    Affiliation: Institute for Community Medicine, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

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  • Ramaiah Nagaraja,

    Affiliation: Laboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Peter Vollenweider,

    Affiliation: Department of Medicine and Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Mark Caulfield,

    Affiliation: The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, England

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  • for the WTCCC,
  • Thomas Illig,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

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  • Christian Gieger mail

    christian.gieger@helmholtz-muenchen.de

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, Germany

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  • Published: June 05, 2009
  • DOI: 10.1371/journal.pgen.1000504

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