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Research Article

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication

  • Sarit Suissa,

    Affiliation: Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Zhibo Wang,

    Affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Jason Poole,

    Affiliations: The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America, Nanogen, Inc., San Diego, California, United States of America

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  • Sharine Wittkopp,

    Affiliation: The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America

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  • Jeanette Feder,

    Affiliation: Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Timothy E. Shutt,

    Affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Douglas C. Wallace,

    Affiliation: The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America

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  • Gerald S. Shadel,

    Affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Dan Mishmar mail

    dmishmar@bgu.ac.il

    Affiliation: Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Published: May 08, 2009
  • DOI: 10.1371/journal.pgen.1000474

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