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Research Article

Measures of Autozygosity in Decline: Globalization, Urbanization, and Its Implications for Medical Genetics

  • Michael A. Nalls,

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Maryland, United States of America

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  • Javier Simon-Sanchez,

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Unidad de Genética Molecular, Departamento de Genómica y Proteómica, Instituto de Biomedicina de Valencia-CSIC, Valencia, Spain

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  • J. Raphael Gibbs,

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom

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  • Coro Paisan-Ruiz,

    Affiliation: Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom

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  • Jose Tomas Bras,

    Affiliation: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Toshiko Tanaka,

    Affiliation: Longitudinal Studies Section, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Mar Matarin,

    Affiliation: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Sonja Scholz,

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom

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  • Charles Weitz,

    Affiliation: Department of Anthropology, Biological Anthropology Program, Temple University, Philadelphia, Pennsylvania, United States of America

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  • Tamara B. Harris,

    Affiliation: Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Maryland, United States of America

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  • Luigi Ferrucci,

    Affiliation: Longitudinal Studies Section, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • John Hardy,

    Affiliation: Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom

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  • Andrew B. Singleton mail

    singleta@mail.nih.gov

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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  • Published: March 13, 2009
  • DOI: 10.1371/journal.pgen.1000415

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