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Research Article

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

  • Tali Gidalevitz,

    Affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America

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  • Thomas Krupinski,

    Affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America

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  • Susana Garcia,

    Affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America

    Current address: Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Richard I. Morimoto mail

    r-morimoto@northwestern.edu

    Affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America

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  • Published: March 06, 2009
  • DOI: 10.1371/journal.pgen.1000399

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