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Research Article

The Novel Mouse Mutation Oblivion Inactivates the PMCA2 Pump and Causes Progressive Hearing Loss

  • Sarah L. Spiden equal contributor,

    equal contributor Contributed equally to this work with: Sarah L. Spiden, Mario Bortolozzi, Francesca Di Leva

    Affiliations: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom, MRC Institute of Hearing Research, University Park, Nottingham, United Kingdom

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  • Mario Bortolozzi equal contributor,

    equal contributor Contributed equally to this work with: Sarah L. Spiden, Mario Bortolozzi, Francesca Di Leva

    Affiliation: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy

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  • Francesca Di Leva equal contributor,

    equal contributor Contributed equally to this work with: Sarah L. Spiden, Mario Bortolozzi, Francesca Di Leva

    Affiliation: Department of Biochemistry and Department of Experimental Veterinary Sciences, University of Padua, Padua, Italy

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  • Martin Hrabé de Angelis,

    Affiliation: Helmholtz Zentrum München, Institute of Experimental Genetics, Neuherberg, Germany

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  • Helmut Fuchs,

    Affiliation: Helmholtz Zentrum München, Institute of Experimental Genetics, Neuherberg, Germany

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  • Dmitry Lim,

    Affiliation: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy

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  • Saida Ortolano,

    Affiliation: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy

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  • Neil J. Ingham,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Marisa Brini,

    Affiliation: Department of Biochemistry and Department of Experimental Veterinary Sciences, University of Padua, Padua, Italy

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  • Ernesto Carafoli,

    Affiliation: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy

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  • Fabio Mammano,

    Affiliations: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy, Department of Physics, University of Padua, Padua, Italy

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  • Karen P. Steel mail

    kps@sanger.ac.uk

    Affiliations: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom, MRC Institute of Hearing Research, University Park, Nottingham, United Kingdom

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  • Published: October 31, 2008
  • DOI: 10.1371/journal.pgen.1000238

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