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Research Article

Discerning the Ancestry of European Americans in Genetic Association Studies

  • Alkes L Price mail,

    To whom correspondence should be addressed. E-mail: aprice@broad.mit.edu (ALP), reich@broad.mit.edu (DR), joelh@broad.mit.edu (JNH)

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Johannah Butler,

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

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  • Nick Patterson,

    Affiliation: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Cristian Capelli,

    Affiliation: Department of Zoology, University of Oxford, Oxford, United Kingdom

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  • Vincenzo L Pascali,

    Affiliation: Forensic Genetics Laboratory, Istituto di Medicina Legale, Universita Cattolica del Sacro Cuore, Rome, Italy

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  • Francesca Scarnicci,

    Affiliation: Forensic Genetics Laboratory, Istituto di Medicina Legale, Universita Cattolica del Sacro Cuore, Rome, Italy

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  • Andres Ruiz-Linares,

    Affiliation: Department of Biology, Galton Laboratory, University College London, United Kingdom

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  • Leif Groop,

    Affiliation: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden

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  • Angelica A Saetta,

    Affiliation: Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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  • Penelope Korkolopoulou,

    Affiliation: Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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  • Uri Seligsohn,

    Affiliation: Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel

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  • Alicja Waliszewska,

    Affiliation: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Christine Schirmer,

    Affiliation: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Kristin Ardlie,

    Affiliation: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Alexis Ramos,

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

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  • James Nemesh,

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

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  • Lori Arbeitman,

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

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  • David B Goldstein,

    Affiliation: Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina, United States of America

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  • David Reich equal contributor mail,

    equal contributor Contributed equally to this work with: David Reich, Joel N Hirschhorn

    To whom correspondence should be addressed. E-mail: aprice@broad.mit.edu (ALP), reich@broad.mit.edu (DR), joelh@broad.mit.edu (JNH)

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Joel N Hirschhorn equal contributor mail

    equal contributor Contributed equally to this work with: David Reich, Joel N Hirschhorn

    To whom correspondence should be addressed. E-mail: aprice@broad.mit.edu (ALP), reich@broad.mit.edu (DR), joelh@broad.mit.edu (JNH)

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Program in Genomics and Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States of America

    X
  • Published: January 18, 2008
  • DOI: 10.1371/journal.pgen.0030236

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Linked Articles

Analysis and Application of European Genetic Substructure Using 300 K SNP Information

Chao Tian, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Selmi, Lars Klareskog, Ann E Pulver, Lihong Qi, Peter K Gregersen, Michael F Seldin
Research Article | published 18 Jan 2008 | PLOS Genetics
doi:10.1371/journal.pgen.0040004

Application of Ancestry Informative Markers to Association Studies in European Americans

Michael F Seldin, Alkes L Price
Perspective | published 18 Jan 2008 | PLOS Genetics
doi:10.1371/journal.pgen.0040005