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Research Article

Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency

  • Adam Kiezun,

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Sara L. Pulit,

    Affiliation: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Laurent C. Francioli,

    Affiliation: Departments of Medical Genetics and of Epidemiology, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Freerk van Dijk,

    Affiliation: Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Morris Swertz,

    Affiliation: Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Dorret I. Boomsma,

    Affiliation: Department of Biological Psychology, VU University, Amsterdam, The Netherlands

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  • Cornelia M. van Duijn,

    Affiliation: Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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  • P. Eline Slagboom,

    Affiliation: Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands

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  • G. J. B. van Ommen,

    Affiliation: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

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  • Cisca Wijmenga,

    Affiliation: Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Genome of the Netherlands Consortium,

    Membership of the Genome of the Netherlands Consortium is provided in the Acknowledgments.

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  • Paul I. W. de Bakker,

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Departments of Medical Genetics and of Epidemiology, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Shamil R. Sunyaev mail

    ssunyaev@rics.bwh.harvard.edu

    Affiliations: Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Published: February 28, 2013
  • DOI: 10.1371/journal.pgen.1003301

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