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Research Article

A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

  • Renee D. Read mail,

    renee.read@emory.edu

    Affiliation: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America

    Current address: Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Tim R. Fenton,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • German G. Gomez,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • Jill Wykosky,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • Scott R. Vandenberg,

    Affiliation: Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Ivan Babic,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • Akio Iwanami,

    Affiliation: Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan

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  • Huijun Yang,

    Affiliation: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

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  • Webster K. Cavenee,

    Affiliations: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, California, United States of America

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  • Paul S. Mischel,

    Affiliations: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America, Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Frank B. Furnari,

    Affiliations: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America, Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • John B. Thomas

    Affiliation: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Published: February 14, 2013
  • DOI: 10.1371/journal.pgen.1003253

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