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Research Article

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

  • Fiona McMurray equal contributor,

    equal contributor Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Chris D. Church equal contributor,

    equal contributor Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Rachel Larder equal contributor,

    equal contributor Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • George Nicholson equal contributor,

    equal contributor Contributed equally to this work with: Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson

    Affiliations: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom, Department of Statistics, University of Oxford, Oxford, United Kingdom

    X
  • Sara Wells,

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Lydia Teboul,

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Y. C. Loraine Tung,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Debra Rimmington,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Fatima Bosch,

    Affiliations: Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    X
  • Veronica Jimenez,

    Affiliations: Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    X
  • Giles S. H. Yeo,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Stephen O'Rahilly,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Frances M. Ashcroft ,

    Affiliation: Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

    These authors also contributed equally to this work.

    X
  • Anthony P. Coll ,

    Affiliation: University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    These authors also contributed equally to this work.

    X
  • Roger D. Cox mail

    r.cox@har.mrc.ac.uk

    Affiliation: MRC Harwell, Harwell Science and Innovation Campus, Harwell, United Kingdom

    These authors also contributed equally to this work.

    X
  • Published: January 03, 2013
  • DOI: 10.1371/journal.pgen.1003166

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