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Research Article

Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent

  • Kin Chan,

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Joan F. Sterling,

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Steven A. Roberts,

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Ashok S. Bhagwat,

    Affiliation: Department of Chemistry, Wayne State University, Detroit, Michigan, United States of America

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  • Michael A. Resnick,

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Dmitry A. Gordenin mail

    gordenin@niehs.nih.gov

    Affiliation: Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Published: December 13, 2012
  • DOI: 10.1371/journal.pgen.1003149

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