Advertisement
Research Article

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

  • Carsten Merkwirth,

    Affiliations: Institute for Genetics, University of Cologne, Cologne, Germany, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany

    Current address: The Salk Institute for Biological Studies, La Jolla, California, United States of America

    X
  • Paola Martinelli equal contributor,

    equal contributor Contributed equally to this work with: Paola Martinelli, Anne Korwitz

    Affiliation: Institute for Zoology, University of Cologne, Cologne, Germany

    X
  • Anne Korwitz equal contributor,

    equal contributor Contributed equally to this work with: Paola Martinelli, Anne Korwitz

    Affiliations: Institute for Genetics, University of Cologne, Cologne, Germany, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany

    X
  • Michela Morbin,

    Affiliation: Neuropathology and Neurology 5, IRCCS Foundation, Neurological Institute Carlo Besta, Milano, Italy

    X
  • Hella S. Brönneke,

    Affiliation: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

    X
  • Sabine D. Jordan,

    Affiliation: Institute for Genetics, University of Cologne, Cologne, Germany

    X
  • Elena I. Rugarli,

    Affiliations: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany, Institute for Zoology, University of Cologne, Cologne, Germany

    X
  • Thomas Langer mail

    Thomas.Langer@uni-koeln.de

    Affiliations: Institute for Genetics, University of Cologne, Cologne, Germany, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany, Max Planck Institute for Biology of Aging, Cologne, Germany

    X
  • Published: November 08, 2012
  • DOI: 10.1371/journal.pgen.1003021

Viewed info

Cited info

Saved info

Discussed info

Questions or concerns about usage data? Please let us know.