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Research Article

A Likelihood-Based Framework for Variant Calling and De Novo Mutation Detection in Families

  • Bingshan Li mail,

    bingshan.li@vanderbilt.edu (BL); goncalo@umich.edu (GA)

    Affiliation: Center for Human Genetics Research, Department of Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Wei Chen,

    Affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Xiaowei Zhan,

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Fabio Busonero,

    Affiliations: Center for Statistical Genetics, Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America, Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Serena Sanna,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Carlo Sidore,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Francesco Cucca,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Hyun M. Kang,

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Gonçalo R. Abecasis mail

    bingshan.li@vanderbilt.edu (BL); goncalo@umich.edu (GA)

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: October 04, 2012
  • DOI: 10.1371/journal.pgen.1002944

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