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Research Article

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

  • Thomas M. Wishart,

    Affiliations: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom, Division of Neurobiology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

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  • Timothy M. Rooney,

    Affiliation: Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Douglas J. Lamont,

    Affiliation: FingerPrints Proteomics Facility, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Ann K. Wright,

    Affiliations: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

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  • A. Jennifer Morton,

    Affiliation: Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom

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  • Mandy Jackson,

    Affiliations: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

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  • Marc R. Freeman,

    Affiliation: Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Thomas H. Gillingwater mail

    T.Gillingwater@ed.ac.uk

    Affiliations: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.pgen.1002936

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