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Research Article

Rare Copy Number Variants Contribute to Congenital Left-Sided Heart Disease

  • Marc-Phillip Hitz,

    Affiliations: Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, Québec, Canada, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Louis-Philippe Lemieux-Perreault,

    Affiliation: Adult Congenital Heart Centre, Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada

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  • Christian Marshall,

    Affiliation: The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Yassamin Feroz-Zada,

    Affiliation: Adult Congenital Heart Centre, Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada

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  • Robbie Davies,

    Affiliation: University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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  • Shi Wei Yang,

    Affiliation: Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, Québec, Canada

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  • Anath Christopher Lionel,

    Affiliation: The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Guylaine D'Amours,

    Affiliation: Service of Medical Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, Québec, Canada

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  • Emmanuelle Lemyre,

    Affiliation: Service of Medical Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, Québec, Canada

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  • Rebecca Cullum,

    Affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • Jean-Luc Bigras,

    Affiliation: Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, Québec, Canada

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  • Maryse Thibeault,

    Affiliation: Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, Québec, Canada

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  • Philippe Chetaille,

    Affiliation: Cardiology Service, Centre Mère-Enfants, Centre Hospitalier Universitaire de Québec, Université de Laval, Québec City, Québec, Canada

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  • Alexandre Montpetit,

    Affiliation: Genome Quebec Innovation Centre, McGill University, Montréal, Québec, Canada

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  • Paul Khairy,

    Affiliation: Adult Congenital Heart Centre, Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada

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  • Bert Overduin,

    Affiliation: European Molecular Biology Laboratory–European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Sabine Klaassen,

    Affiliation: Experimental and Clinical Research Center, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

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  • Pamela Hoodless,

    Affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • Mona Nemer,

    Affiliation: Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada

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  • Alexandre F. R. Stewart,

    Affiliation: Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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  • Cornelius Boerkoel,

    Affiliation: Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

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  • Stephen W. Scherer,

    Affiliation: The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Andrea Richter,

    Affiliation: Service of Medical Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, Québec, Canada

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  • Marie-Pierre Dubé,

    Affiliation: Adult Congenital Heart Centre, Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada

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  • Gregor Andelfinger mail

    gregor.andelfinger@recherche-ste-justine.qc.ca

    Affiliation: Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, Québec, Canada

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  • Published: September 06, 2012
  • DOI: 10.1371/journal.pgen.1002903

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