Advertisement
Research Article

Exome Sequencing Identifies Rare Deleterious Mutations in DNA Repair Genes FANCC and BLM as Potential Breast Cancer Susceptibility Alleles

  • Ella R. Thompson,

    Affiliation: Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • Maria A. Doyle,

    Affiliation: Bioinformatics Core Facility, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • Georgina L. Ryland,

    Affiliations: Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia

    X
  • Simone M. Rowley,

    Affiliation: Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • David Y. H. Choong,

    Affiliation: Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • Richard W. Tothill,

    Affiliation: Molecular Genomics Core Facility, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • Heather Thorne,

    Affiliation: Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • kConFab,

    Affiliation: Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • Daniel R. Barnes,

    Affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Jason Li,

    Affiliation: Bioinformatics Core Facility, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • Jason Ellul,

    Affiliation: Bioinformatics Core Facility, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • Gayle K. Philip,

    Affiliation: Life Sciences Computation Centre, Victorian Life Sciences Computation Initiative, Carlton, Victoria, Australia

    X
  • Yoland C. Antill,

    Affiliation: Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • Paul A. James,

    Affiliations: Familial Cancer Centre, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia

    X
  • Alison H. Trainer,

    Affiliations: Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, Familial Cancer Centre, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    X
  • Gillian Mitchell,

    Affiliations: Familial Cancer Centre, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia

    X
  • Ian G. Campbell mail

    ian.campbell@petermac.org

    Affiliations: Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia

    X
  • Published: September 27, 2012
  • DOI: 10.1371/journal.pgen.1002894

Viewed info

Cited info

Saved info

Discussed info

Questions or concerns about usage data? Please let us know.