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Research Article

The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

  • Benjamin F. Voight equal contributor,

    equal contributor Contributed equally to this work with: Benjamin F. Voight, Hyun Min Kang

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Hyun Min Kang equal contributor,

    equal contributor Contributed equally to this work with: Benjamin F. Voight, Hyun Min Kang

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jun Ding,

    Affiliation: Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Cameron D. Palmer,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America

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  • Carlo Sidore,

    Affiliations: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America, Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

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  • Peter S. Chines,

    Affiliation: Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America

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  • Noël P. Burtt,

    Affiliation: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Christian Fuchsberger,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Yanming Li,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jeanette Erdmann,

    Affiliation: Universität zu Lübeck, Medizinische Klinik II, and Nordic Center of Cardiovascular Research, Lübeck, Germany

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  • Timothy M. Frayling,

    Affiliation: Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom

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  • Iris M. Heid,

    Affiliations: Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany, Helmholtz Zentrum München—German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany

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  • Anne U. Jackson,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Toby Johnson,

    Affiliation: Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom

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  • Tuomas O. Kilpeläinen,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Cecilia M. Lindgren,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Andrew P. Morris,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Inga Prokopenko,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Joshua C. Randall,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Richa Saxena,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Nicole Soranzo,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Elizabeth K. Speliotes,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Internal Medicine, Division of Gastroenterology and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Tanya M. Teslovich,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Eleanor Wheeler,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Jared Maguire,

    Affiliation: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Melissa Parkin,

    Affiliation: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Simon Potter,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • N. William Rayner,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Neil Robertson,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Kathleen Stirrups,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Wendy Winckler,

    Affiliation: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Serena Sanna,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Antonella Mulas,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Ramaiah Nagaraja,

    Affiliation: Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Francesco Cucca,

    Affiliations: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

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  • Inês Barroso,

    Affiliations: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Panos Deloukas,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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  • Ruth J. F. Loos,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Sekar Kathiresan,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Patricia B. Munroe,

    Affiliation: Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom

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  • Christopher Newton-Cheh,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Arne Pfeufer,

    Affiliations: Institute of Human Genetics, Klinikum Rechts der Isar Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany, EURAC Center of Biomedicine, Bolzano, Italy

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  • Nilesh J. Samani,

    Affiliations: Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom, Leicester NIHR Biomedical Research Unit in Coronary Artery Disease, Glenfield Hospital, Leicester, United Kingdom

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  • Heribert Schunkert,

    Affiliation: Universität zu Lübeck, Medizinische Klinik II, and Nordic Center of Cardiovascular Research, Lübeck, Germany

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  • Joel N. Hirschhorn,

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • David Altshuler mail,

    altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

    Affiliations: Medical Population Genetics, The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Molecular Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Mark I. McCarthy mail,

    altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

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  • Gonçalo R. Abecasis mail,

    altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Michael Boehnke mail

    altshuler@molbio.mgh.harvard.edu (DA); mark.mccarthy@drl.ox.ac.uk (MIM); goncalo@umich.edu (GRA); boehnke@umich.edu (MB)

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.pgen.1002793

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