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Research Article

Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity

  • Mitsuhiro Endoh mail,

    mendoh@rcai.riken.jp (ME); koseki@rcai.riken.jp (HK)

    Affiliations: Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Yokohama, Japan

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  • Takaho A. Endo equal contributor,

    equal contributor Contributed equally to this work with: Takaho A. Endo, Tamie Endoh

    Affiliation: RIKEN Bioinformatics and System Engineering Division, Yokohama, Japan

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  • Tamie Endoh equal contributor,

    equal contributor Contributed equally to this work with: Takaho A. Endo, Tamie Endoh

    Affiliation: Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan

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  • Kyo-ichi Isono,

    Affiliation: Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan

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  • Jafar Sharif,

    Affiliation: Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan

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  • Osamu Ohara,

    Affiliation: Laboratories for Immunogenomics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan

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  • Tetsuro Toyoda,

    Affiliation: RIKEN Bioinformatics and System Engineering Division, Yokohama, Japan

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  • Takashi Ito,

    Affiliation: Department of Biochemistry, Nagasaki University School of Medicine, Nagasaki, Japan

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  • Ragnhild Eskeland,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Wendy A. Bickmore,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Miguel Vidal,

    Affiliations: Cell Proliferation and Development, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain, Research Unit for Immunoepigenetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan

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  • Bradley E. Bernstein,

    Affiliations: Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Haruhiko Koseki mail

    mendoh@rcai.riken.jp (ME); koseki@rcai.riken.jp (HK)

    Affiliations: Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Yokohama, Japan

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.pgen.1002774

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