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Research Article

Meta-Analysis of Genome-Wide Scans for Total Body BMD in Children and Adults Reveals Allelic Heterogeneity and Age-Specific Effects at the WNT16 Locus

  • Carolina Medina-Gomez equal contributor,

    equal contributor Contributed equally to this work with: Carolina Medina-Gomez, John P. Kemp

    Affiliations: Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)–sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands

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  • John P. Kemp equal contributor,

    equal contributor Contributed equally to this work with: Carolina Medina-Gomez, John P. Kemp

    Affiliations: MRC CAiTE Centre, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Karol Estrada,

    Affiliations: Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)–sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands

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  • Joel Eriksson,

    Affiliation: Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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  • Jeff Liu,

    Affiliation: Lexicon Pharmaceuticals, The Woodlands, Texas, United States of America

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  • Sjur Reppe,

    Affiliation: Department of Medical Biochemistry, Oslo University Hospital, Ullevaal, Oslo, Norway

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  • David M. Evans,

    Affiliations: MRC CAiTE Centre, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Denise H. M. Heppe,

    Affiliations: The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Pediatrics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Liesbeth Vandenput,

    Affiliation: Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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  • Lizbeth Herrera,

    Affiliation: Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Susan M. Ring,

    Affiliation: Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Claudia J. Kruithof,

    Affiliations: The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Nicholas J. Timpson,

    Affiliations: MRC CAiTE Centre, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • M. Carola Zillikens,

    Affiliations: Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)–sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands

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  • Ole K. Olstad,

    Affiliation: Department of Medical Biochemistry, Oslo University Hospital, Ullevaal, Oslo, Norway

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  • Hou-Feng Zheng,

    Affiliations: Department of Medicine, Human Genetics, McGill University, Montreal, Quebec, Canada, Department of Epidemiology and Biostatistics, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada

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  • J. Brent Richards,

    Affiliations: Department of Medicine, Human Genetics, McGill University, Montreal, Quebec, Canada, Department of Epidemiology and Biostatistics, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada, Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Beate St. Pourcain,

    Affiliation: MRC CAiTE Centre, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Albert Hofman,

    Affiliations: The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)–sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands

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  • Vincent W. V. Jaddoe,

    Affiliations: The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Pediatrics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • George Davey Smith,

    Affiliations: MRC CAiTE Centre, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Mattias Lorentzon,

    Affiliation: Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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  • Kaare M. Gautvik,

    Affiliations: Department of Medical Biochemistry, Oslo University Hospital, Ullevaal, Oslo, Norway, Department of Medical Biochemistry, Oslo Deacon Hospital, Oslo, Norway

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  • André G. Uitterlinden,

    Affiliations: Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)–sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands

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  • Robert Brommage,

    Affiliation: Lexicon Pharmaceuticals, The Woodlands, Texas, United States of America

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  • Claes Ohlsson,

    Affiliation: Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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  • Jonathan H. Tobias,

    Affiliation: School of Clinical Sciences, University of Bristol, Bristol, United Kingdom

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  • Fernando Rivadeneira mail

    f.rivadeneira@erasmusmc.nl

    Affiliations: Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands, The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative (NGI)–sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands

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  • Published: July 05, 2012
  • DOI: 10.1371/journal.pgen.1002718

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