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Research Article

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

  • Zari Dastani equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliation: Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada

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  • Marie-France Hivert equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliations: Department of Medicine, Université de Sherbrooke, Sherbrooke, Canada, General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Nicholas Timpson equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliation: MRC CAiTE Centre and School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

    X
  • John R. B. Perry equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

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  • Xin Yuan equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliation: Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

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  • Robert A. Scott equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Peter Henneman equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliation: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

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  • Iris M. Heid equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliation: Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany

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  • Jorge R. Kizer equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliation: Departments of Medicine and Public Health, Weill Cornell Medical College, New York, New York, United States of America

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  • Leo-Pekka Lyytikäinen equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliation: Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Christian Fuchsberger equal contributor,

    equal contributor Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Toshiko Tanaka,

    Affiliation: Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Andrew P. Morris,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Kerrin Small,

    Affiliations: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Aaron Isaacs,

    Affiliations: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Centre for Medical Systems Biology, Leiden, The Netherlands

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  • Marian Beekman,

    Affiliation: Section of Molecular Epidemiology, Leiden University Medical Center and The Netherlands Genomics Initiative, The Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

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  • Stefan Coassin,

    Affiliation: Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

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  • Kurt Lohman,

    Affiliation: Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Lu Qi,

    Affiliation: Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Stavroula Kanoni,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • James S. Pankow,

    Affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Hae-Won Uh,

    Affiliation: Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands

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  • Ying Wu,

    Affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Aurelian Bidulescu,

    Affiliation: Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia, United States of America

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  • Laura J. Rasmussen-Torvik,

    Affiliation: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Celia M. T. Greenwood,

    Affiliation: Lady Davis Institute for Medical Research, Department of Oncology, McGill University, Montreal, Canada

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  • Martin Ladouceur,

    Affiliation: Department of Human Genetics McGill University, Montreal, Canada

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  • Jonna Grimsby,

    Affiliations: General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Alisa K. Manning,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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  • Ching-Ti Liu,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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  • Jaspal Kooner,

    Affiliation: Cardiology, Ealing Hospital National Health Service (NHS) Trust, London, United Kingdom

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  • Vincent E. Mooser,

    Affiliation: Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

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  • Peter Vollenweider,

    Affiliation: Department of Internal Medicine, University of Lausanne, Lausanne, Switzerland

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  • Karen A. Kapur,

    Affiliation: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

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  • John Chambers,

    Affiliation: Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

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  • Nicholas J. Wareham,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Claudia Langenberg,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Rune Frants,

    Affiliation: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

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  • Ko Willems-vanDijk,

    Affiliation: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

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  • Ben A. Oostra,

    Affiliations: Centre for Medical Systems Biology, Leiden, The Netherlands, Deptartment of Clinical Genetics and Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Sara M. Willems,

    Affiliation: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Claudia Lamina,

    Affiliation: Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

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  • Thomas W. Winkler,

    Affiliation: Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany

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  • Bruce M. Psaty,

    Affiliations: Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

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  • Russell P. Tracy,

    Affiliation: Departments of Pathology and Biochemistry, University of Vermont, Burlington, Vermont, United States of America

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  • Jennifer Brody,

    Affiliation: Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America

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  • Ida Chen,

    Affiliation: Medical Genetics Research Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America

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  • Jorma Viikari,

    Affiliation: Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

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  • Mika Kähönen,

    Affiliation: Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Peter P. Pramstaller,

    Affiliations: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, Italy, Department of Neurology, General Central Hospital, Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany

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  • David M. Evans,

    Affiliation: MRC CAiTE Centre and School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

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  • Beate St. Pourcain,

    Affiliation: School of Social and community medicine, University of Bristol, Bristol, United Kingdom

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  • Naveed Sattar,

    Affiliation: British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Andrew R. Wood,

    Affiliation: Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

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  • Stefania Bandinelli,

    Affiliation: Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy

    X
  • Olga D. Carlson,

    Affiliation: Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland, United States of America

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  • Josephine M. Egan,

    Affiliation: Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland, United States of America

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  • Stefan Böhringer,

    Affiliation: Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands

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  • Diana van Heemst,

    Affiliation: Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

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  • Lyudmyla Kedenko,

    Affiliation: First Department of Internal Medicine, St. Johann Spital, Paracelsus Private Medical University Salzburg, Salzburg, Austria

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  • Kati Kristiansson,

    Affiliation: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, and Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland

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  • Marja-Liisa Nuotio,

    Affiliation: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, and Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland

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  • Britt-Marie Loo,

    Affiliation: Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland

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  • Tamara Harris,

    Affiliation: Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Melissa Garcia,

    Affiliation: Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Alka Kanaya,

    Affiliation: Division of General Internal Medicine, Women's Health Clinical Research Center, University of California San Francisco, San Francisco, California, United States of America

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  • Margot Haun,

    Affiliation: Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

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  • Norman Klopp,

    Affiliation: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany

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  • H.-Erich Wichmann,

    Affiliations: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, Klinikum Großhadern, Munich, Germany

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  • Panos Deloukas,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Efi Katsareli,

    Affiliation: Harokopio University, Athens, Greece

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  • David J. Couper,

    Affiliation: Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Bruce B. Duncan,

    Affiliations: School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Margreet Kloppenburg,

    Affiliation: Department of Rheumatology and Department of Clinical Epidemiology, Leiden, The Netherlands

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  • Linda S. Adair,

    Affiliation: Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Judith B. Borja,

    Affiliation: Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines

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  • DIAGRAM+ Consortium ,

    ‡ Memberships of these consortia are provided in the Acknowledgments.

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  • MAGIC Consortium ,

    ‡ Memberships of these consortia are provided in the Acknowledgments.

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  • GLGC Investigators ,

    ‡ Memberships of these consortia are provided in the Acknowledgments.

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  • MuTHER Consortium ,

    ‡ Memberships of these consortia are provided in the Acknowledgments.

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  • James G. Wilson,

    Affiliation: Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Solomon Musani,

    Affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Xiuqing Guo,

    Affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

    X
  • Toby Johnson,

    Affiliations: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, University Institute of Social and Preventative Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Robert Semple,

    Affiliation: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Tanya M. Teslovich,

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Matthew A. Allison,

    Affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, United States of America

    X
  • Susan Redline,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Sarah G. Buxbaum,

    Affiliation: Jackson Heart Study Coordinating Center, Jackson State University, Jackson, Mississippi, United States of America

    X
  • Karen L. Mohlke,

    Affiliation: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Ingrid Meulenbelt,

    Affiliation: Section of Molecular Epidemiology, Leiden University Medical Center and The Netherlands Genomics Initiative, The Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

    X
  • Christie M. Ballantyne,

    Affiliation: Baylor College of Medicine and Methodist DeBakey Heart and Vascular Center, Houston, Texas, United States of America

    X
  • George V. Dedoussis,

    Affiliation: Harokopio University, Athens, Greece

    X
  • Frank B. Hu,

    Affiliation: Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Yongmei Liu,

    Affiliation: Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Bernhard Paulweber,

    Affiliation: First Department of Internal Medicine, St. Johann Spital, Paracelsus Private Medical University Salzburg, Salzburg, Austria

    X
  • Timothy D. Spector,

    Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

    X
  • P. Eline Slagboom,

    Affiliation: Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

    X
  • Luigi Ferrucci,

    Affiliation: Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America

    X
  • Antti Jula,

    Affiliation: Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland

    X
  • Markus Perola,

    Affiliation: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, and Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland

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  • Olli Raitakari,

    Affiliation: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and the Department of Clinical Physiology, Turku University Hospital, Turku, Finland

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  • Jose C. Florez,

    Affiliations: Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Veikko Salomaa ,

    Affiliation: Chronic Disease Epidemiology and Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

    These authors also contributed equally to this work.

    X
  • Johan G. Eriksson ,

    Affiliations: Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland, Folkhalsan Research Centre, Helsinki, Finland, Vaasa Central Hospital, Vaasa, Finland, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland

    These authors also contributed equally to this work.

    X
  • Timothy M. Frayling ,

    Affiliation: Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

    These authors also contributed equally to this work.

    X
  • Andrew A. Hicks ,

    Affiliation: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, Italy

    These authors also contributed equally to this work.

    X
  • Terho Lehtimäki ,

    Affiliation: Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland

    These authors also contributed equally to this work.

    X
  • George Davey Smith ,

    Affiliation: MRC CAiTE Centre and School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

    These authors also contributed equally to this work.

    X
  • David S. Siscovick ,

    Affiliation: University of Washington, Seattle, Washington, United States of America

    These authors also contributed equally to this work.

    X
  • Florian Kronenberg ,

    Affiliation: Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria

    These authors also contributed equally to this work.

    X
  • Cornelia van Duijn ,

    Affiliations: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Centre for Medical Systems Biology, Leiden, The Netherlands

    These authors also contributed equally to this work.

    X
  • Ruth J. F. Loos ,

    Affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

    These authors also contributed equally to this work.

    X
  • Dawn M. Waterworth ,

    Affiliation: Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

    These authors also contributed equally to this work.

    X
  • James B. Meigs ,

    Affiliations: General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

    These authors also contributed equally to this work.

    X
  • Josee Dupuis ,

    Affiliations: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

    These authors also contributed equally to this work.

    X
  • J. Brent Richards mail

    brent.richards@mcgill.ca

    Affiliations: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Departments of Medicine, Human Genetics, Epidemiology, and Biostatistics, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Canada

    X
  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002607

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