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Research Article

Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure

  • Emília Ilona Gaál mail,

    emilia.gaal@helsinki.fi

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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  • Perttu Salo equal contributor,

    equal contributor Contributed equally to this work with: Perttu Salo, Kati Kristiansson

    Affiliation: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Kati Kristiansson equal contributor,

    equal contributor Contributed equally to this work with: Perttu Salo, Kati Kristiansson

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Karola Rehnström,

    Affiliations: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Johannes Kettunen,

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Antti-Pekka Sarin,

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Mika Niemelä,

    Affiliation: Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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  • Antti Jula,

    Affiliation: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Olli T. Raitakari,

    Affiliations: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology, University of Turku and Turku University Hospital, Turku, Finland

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  • Terho Lehtimäki,

    Affiliation: Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Johan G. Eriksson,

    Affiliations: Diabetes Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Department of General Practice and Primary Health Care, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland, Vasa Central Hospital, Vasa, Finland, Folkhälsan Research Centre, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland

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  • Elisabeth Widen,

    Affiliation: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

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  • Murat Günel,

    Affiliation: Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Mitja Kurki,

    Affiliation: Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland

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  • Mikael von und zu Fraunberg,

    Affiliation: Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland

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  • Juha E. Jääskeläinen,

    Affiliation: Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland

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  • Juha Hernesniemi,

    Affiliation: Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland

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  • Marjo-Riitta Järvelin,

    Affiliations: Department of Biostatistics and Epidemiology, School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland

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  • Anneli Pouta,

    Affiliation: Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland

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  • The International Consortium for Blood Pressure Genome-Wide Association Studies (ICBP-GWAS),

    Membership of the ICBP-GWAS is available in Text S1.

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  • Christopher Newton-Cheh,

    Affiliations: Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Veikko Salomaa,

    Affiliation: Chronic Disease Epidemiology and Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Aarno Palotie,

    Affiliations: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

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  • Markus Perola

    Affiliations: Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, University of Tartu, Estonian Genome Centre, Tartu, Estonia

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pgen.1002563

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