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Research Article

Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

  • Christina M. Lill,

    Affiliations: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Neurology, Medical Center of the Johannes Gutenberg-University, Mainz, Germany, Department of Neurology, University Hospital, Münster, Germany

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  • Johannes T. Roehr,

    Affiliations: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, Department of Mathematics and Computer Science, Free University, Berlin, Germany

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  • Matthew B. McQueen,

    Affiliation: Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, United States of America

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  • Fotini K. Kavvoura,

    Affiliations: Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, Centre for Diabetes and Endocrinology, Royal Berkshire Hospital, Reading, United Kingdom, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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  • Sachin Bagade,

    Affiliation: Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Brit-Maren M. Schjeide,

    Affiliation: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Leif M. Schjeide,

    Affiliation: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Esther Meissner,

    Affiliation: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Ute Zauft,

    Affiliation: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Nicole C. Allen,

    Affiliation: Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Tian Liu,

    Affiliations: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, Max Planck Institute for Human Development, Berlin, Germany

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  • Marcel Schilling,

    Affiliations: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, Department of Mathematics and Computer Science, Free University, Berlin, Germany

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  • Kari J. Anderson,

    Affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Gary Beecham,

    Affiliation: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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  • Daniela Berg,

    Affiliations: Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany, DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany

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  • Joanna M. Biernacka,

    Affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Alexis Brice,

    Affiliations: INSERM, UMR_S975, Paris, France, Université Pierre et Marie Curie-Paris, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France, CNRS, UMR 7225, Paris, France, AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France

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  • Anita L. DeStefano,

    Affiliations: Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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  • Chuong B. Do,

    Affiliation: 23andMe, Mountain View, California, United States of America

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  • Nicholas Eriksson,

    Affiliation: 23andMe, Mountain View, California, United States of America

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  • Stewart A. Factor,

    Affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Matthew J. Farrer,

    Affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, Canada

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  • Tatiana Foroud,

    Affiliation: Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Thomas Gasser,

    Affiliations: Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany, DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany

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  • Taye Hamza,

    Affiliation: New York State Department of Health Wadsworth Center, Albany, New York, United States of America

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  • John A. Hardy,

    Affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom

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  • Peter Heutink,

    Affiliation: Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands

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  • Erin M. Hill-Burns,

    Affiliation: New York State Department of Health Wadsworth Center, Albany, New York, United States of America

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  • Christine Klein,

    Affiliation: Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lübeck, Lübeck, Germany

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  • Jeanne C. Latourelle,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, United States of America

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  • Demetrius M. Maraganore,

    Affiliation: Department of Neurology, NorthShore University Health System, Evanston, Illinois, United States of America

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  • Eden R. Martin,

    Affiliation: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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  • Maria Martinez,

    Affiliations: INSERM UMR 1043, CPTP, Toulouse, France, Paul Sabatier University, Toulouse, France

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  • Richard H. Myers,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, United States of America

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  • Michael A. Nalls,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Nathan Pankratz,

    Affiliation: Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Haydeh Payami,

    Affiliation: New York State Department of Health Wadsworth Center, Albany, New York, United States of America

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  • Wataru Satake,

    Affiliation: Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan

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  • William K. Scott,

    Affiliation: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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  • Manu Sharma,

    Affiliations: Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany, DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany

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  • Andrew B. Singleton,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Kari Stefansson,

    Affiliation: deCODE genetics, Reykjavik, Iceland

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  • Tatsushi Toda,

    Affiliation: Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan

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  • Joyce Y. Tung,

    Affiliation: 23andMe, Mountain View, California, United States of America

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  • Jeffery Vance,

    Affiliation: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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  • Nick W. Wood,

    Affiliations: UCL Genetics Institute, University College London, London, United Kingdom, Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom

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  • Cyrus P. Zabetian,

    Affiliation: VA Puget Sound Health Care System and Department of Neurology, University of Washington, Seattle, Washington, United States of America

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  • 23andMe, The Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium ,

    Memberships of the consortia are provided in Text S1.

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  • The International Parkinson's Disease Genomics Consortium (IPDGC) ,

    Memberships of the consortia are provided in Text S1.

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  • The Parkinson's Disease GWAS Consortium ,

    Memberships of the consortia are provided in Text S1.

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  • The Wellcome Trust Case Control Consortium 2 (WTCCC2) ,

    Memberships of the consortia are provided in Text S1.

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  • Peter Young,

    Affiliation: Department of Neurology, University Hospital, Münster, Germany

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  • Rudolph E. Tanzi,

    Affiliation: Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Muin J. Khoury,

    Affiliation: Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Frauke Zipp,

    Affiliation: Department of Neurology, Medical Center of the Johannes Gutenberg-University, Mainz, Germany

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  • Hans Lehrach,

    Affiliation: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • John P. A. Ioannidis,

    Affiliations: Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, Biomedical Research Institute, Foundation for Research and Technology–Hellas, Ioannina, Greece, Center for Genetic Epidemiology and Modeling and Tufts Clinical and Translational Science Institute, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Stanford Prevention Research Center, Department of Medicine and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America

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  • Lars Bertram mail

    lbertram@molgen.mpg.de

    Affiliations: Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pgen.1002548

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