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Research Article

LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients

  • MyLinh T. Duong,

    Affiliations: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, United States of America

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  • Said Akli,

    Affiliation: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Caimiao Wei,

    Affiliation: Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Hannah F. Wingate,

    Affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Wenbin Liu,

    Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Yiling Lu,

    Affiliation: Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Min Yi,

    Affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Gordon B. Mills,

    Affiliations: Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, United States of America, Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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  • Kelly K. Hunt mail,

    kkeyomar@mdanderson.org (KK); khunt@mdanderson.org (KKH)

    Affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Khandan Keyomarsi mail

    kkeyomar@mdanderson.org (KK); khunt@mdanderson.org (KKH)

    Affiliations: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas, United States of America

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  • Published: March 29, 2012
  • DOI: 10.1371/journal.pgen.1002538

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