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Research Article

The Empirical Power of Rare Variant Association Methods: Results from Sanger Sequencing in 1,998 Individuals

  • Martin Ladouceur,

    Affiliations: Department of Human Genetics, McGill University, Montreal, Canada, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada

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  • Zari Dastani,

    Affiliations: Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada

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  • Yurii S. Aulchenko,

    Affiliations: Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia

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  • Celia M. T. Greenwood,

    Affiliations: Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada, Department of Oncology, McGill University, Montreal, Canada

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  • J. Brent Richards mail

    brent.richards@mcgill.ca

    Affiliations: Department of Human Genetics, McGill University, Montreal, Canada, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada, Department of Medicine, Jewish General Hospital, McGill University, Montreal, Canada, Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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  • Published: February 02, 2012
  • DOI: 10.1371/journal.pgen.1002496

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