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Research Article

Identification of Evolutionarily Conserved Exons as Regulated Targets for the Splicing Activator Tra2β in Development

  • Sushma Grellscheid equal contributor mail,

    equal contributor Contributed equally to this work with: Sushma Grellscheid, Caroline Dalgliesh, Markus Storbeck

    sushma@cantab.net (SG); David.Elliott@ncl.ac.uk (DE)

    Affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom

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  • Caroline Dalgliesh equal contributor,

    equal contributor Contributed equally to this work with: Sushma Grellscheid, Caroline Dalgliesh, Markus Storbeck

    Affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom

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  • Markus Storbeck equal contributor,

    equal contributor Contributed equally to this work with: Sushma Grellscheid, Caroline Dalgliesh, Markus Storbeck

    Affiliations: Institute of Human Genetics, University of Cologne, Cologne, Germany, Institute of Genetics, University of Cologne, Cologne, Germany, Center for Molecular Medicine, University of Cologne, Cologne, Germany

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  • Andrew Best,

    Affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom

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  • Yilei Liu,

    Affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom

    Current address: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

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  • Miriam Jakubik,

    Affiliations: Institute of Human Genetics, University of Cologne, Cologne, Germany, Institute of Genetics, University of Cologne, Cologne, Germany, Center for Molecular Medicine, University of Cologne, Cologne, Germany

    X
  • Ylva Mende,

    Affiliations: Institute of Human Genetics, University of Cologne, Cologne, Germany, Institute of Genetics, University of Cologne, Cologne, Germany, Center for Molecular Medicine, University of Cologne, Cologne, Germany

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  • Ingrid Ehrmann,

    Affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom

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  • Tomaz Curk,

    Affiliation: University of Ljubljana, Faculty of Computer and Information Science, Ljubljana, Slovenia

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  • Kristina Rossbach,

    Affiliations: Institute of Human Genetics, University of Cologne, Cologne, Germany, Institute of Genetics, University of Cologne, Cologne, Germany, Center for Molecular Medicine, University of Cologne, Cologne, Germany

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  • Cyril F. Bourgeois,

    Affiliation: Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U 964, CNRS UMR 7104, Université de Strasbourg, Illkirch, France

    Current address: INSERM 1052 / CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France

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  • James Stévenin,

    Affiliation: Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U 964, CNRS UMR 7104, Université de Strasbourg, Illkirch, France

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  • David Grellscheid,

    Affiliation: Institute for Particle Physics Phenomenology, Durham University, Durham, United Kingdom

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  • Michael S. Jackson,

    Affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom

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  • Brunhilde Wirth,

    Affiliations: Institute of Human Genetics, University of Cologne, Cologne, Germany, Institute of Genetics, University of Cologne, Cologne, Germany, Center for Molecular Medicine, University of Cologne, Cologne, Germany

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  • David J. Elliott mail

    sushma@cantab.net (SG); David.Elliott@ncl.ac.uk (DE)

    Affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom

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  • Published: December 15, 2011
  • DOI: 10.1371/journal.pgen.1002390

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