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Research Article

Pervasive Sharing of Genetic Effects in Autoimmune Disease

  • Chris Cotsapas equal contributor,

    equal contributor Contributed equally to this work with: Chris Cotsapas, Benjamin F. Voight

    Affiliations: Center For Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Benjamin F. Voight equal contributor,

    equal contributor Contributed equally to this work with: Chris Cotsapas, Benjamin F. Voight

    Affiliations: Center For Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Elizabeth Rossin,

    Affiliations: Center For Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Health Science and Technology MD Program, Harvard University and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America, Harvard Biological and Biomedical Sciences Program, Harvard University, Boston, Massachusetts, United States of America

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  • Kasper Lage,

    Affiliations: Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

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  • Benjamin M. Neale,

    Affiliations: Center For Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Analytical and Translational Genetics Unity, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Chris Wallace,

    Affiliation: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

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  • Gonçalo R. Abecasis,

    Affiliation: Center for Statistical Genetics, University of Michigan, Ann Arbor, Massachusetts, United States of America

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  • Jeffrey C. Barrett,

    Affiliation: Human Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

    X
  • Timothy Behrens,

    Affiliation: Genentech, South San Francisco, California, United States of America

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  • Judy Cho,

    Affiliations: Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America, Departments of Medicine and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Philip L. De Jager,

    Affiliations: Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • James T. Elder,

    Affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Robert R. Graham,

    Affiliation: Genentech, South San Francisco, California, United States of America

    X
  • Peter Gregersen,

    Affiliation: Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America

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  • Lars Klareskog,

    Affiliation: Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Katherine A. Siminovitch,

    Affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

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  • David A. van Heel,

    Affiliation: Blizard Institute, The London School of Medicine and Dentistry, London, United Kingdom

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  • Cisca Wijmenga,

    Affiliation: Department of Genetics, University Medical Center Groningen and Groningen University, Groningen, The Netherlands

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  • Jane Worthington,

    Affiliation: Arthritis Research UK Epidemiology Unit, School of Translational Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom

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  • John A. Todd,

    Affiliation: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

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  • David A. Hafler,

    Affiliation: Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Stephen S. Rich,

    Affiliation: Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

    X
  • Mark J. Daly mail,

    mjdaly@atgu.mgh.harvard.edu

    Affiliations: Center For Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Analytical and Translational Genetics Unity, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • on behalf of the FOCiS Network of Consortia
  • Published: August 10, 2011
  • DOI: 10.1371/journal.pgen.1002254

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