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Research Article

Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability

  • Serena Sanna equal contributor mail,

    equal contributor Contributed equally to this work with: Serena Sanna, Bingshan Li, Antonella Mulas

    goncalo@umich.edu (GRA); serena.sanna@inn.cnr.it (SS)

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Bingshan Li equal contributor,

    equal contributor Contributed equally to this work with: Serena Sanna, Bingshan Li, Antonella Mulas

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Antonella Mulas equal contributor,

    equal contributor Contributed equally to this work with: Serena Sanna, Bingshan Li, Antonella Mulas

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Carlo Sidore,

    Affiliations: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

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  • Hyun M. Kang,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Anne U. Jackson,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Maria Grazia Piras,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Gianluca Usala,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • Giuseppe Maninchedda,

    Affiliation: Shardna Life Sciences, Pula, Italy

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  • Alessandro Sassu,

    Affiliation: Shardna Life Sciences, Pula, Italy

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  • Fabrizio Serra,

    Affiliation: Shardna Life Sciences, Pula, Italy

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  • Maria Antonietta Palmas,

    Affiliation: Shardna Life Sciences, Pula, Italy

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  • William H. Wood III,

    Affiliation: Gene Expression and Genomics Unit, Research Resources Branch, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Inger Njølstad,

    Affiliation: Department of Community Medicine, Faculty of Health Sciences, University of Tromso, Tromso, Norway

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  • Markku Laakso,

    Affiliation: Department of Medicine, University of Eastern Finland, Kuopio, Finland

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  • Kristian Hveem,

    Affiliation: Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

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  • Jaakko Tuomilehto,

    Affiliations: Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland, Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland, South Ostrobothnia Central Hospital, Seinajoki, Finland

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  • Timo A. Lakka,

    Affiliations: Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

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  • Rainer Rauramaa,

    Affiliation: Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

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  • Michael Boehnke,

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Francesco Cucca,

    Affiliations: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy, Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

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  • Manuela Uda,

    Affiliation: Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

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  • David Schlessinger ,

    Affiliation: Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America

    These authors also contributed equally to this work.

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  • Ramaiah Nagaraja ,

    Affiliation: Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America

    These authors also contributed equally to this work.

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  • Gonçalo R. Abecasis mail

    goncalo@umich.edu (GRA); serena.sanna@inn.cnr.it (SS)

    Affiliation: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

    These authors also contributed equally to this work.

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  • Published: July 28, 2011
  • DOI: 10.1371/journal.pgen.1002198

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